Agent Name

2-Butoxyethanol

Alternative Name

EGBE

CAS Number

111-76-2

Formula

C6-H14-O2

Major Category

Solvents

Synonyms

Ethylene glycol monobutyl ether; 2-Butoxy-1-ethanol; 2-; 2-Butoxyethanol; 3-Oxa-1-heptanol; BUCS; Butoxyethanol; Butyl cellosolve; Butyl cellu-sol; Butyl glycol; Butyl oxitol; Chimec NR; Dowanol EB; EGBE; EGMBE; Ektasolve EB; Ethanol, 2-butoxy-; Ethylene glycol butyl ether; Ethylene glycol n-butyl ether; Ethylene glycol, monobutyl ether; Gafcol EB; Glycol butyl ether; Glycol ether EB; Glycol monobutyl ether; Jeffersol EB; Monobutyl ether of ethylene glycol; Monobutyl ethylene glycol ether; O-Butyl ethylene glycol; Poly-Solv EB; n-Butoxyethanol; [ChemIDplus] UN2369

Category

Glycol Ethers (E Series)

Description

Colorless liquid with a mild, ether-like odor; [NIOSH]

Sources/Uses

Used as solvent in surface coatings; [ACGIH] Also used in hydraulic fluids, glass cleaners, and leather cleaners; [Sullivan, p. 1203] Used as a solvent in paints, coatings, inks, metal cleaners, and household cleaners; Occupational exposures are high in silk screen printing; [Reference #2]

Comments

Severe hemoglobinuria and changes in the lungs, kidneys, and liver are seen in mice after 7-hour lethal concentration studies. Volunteers showed no evidence of adverse effects other than mucous membrane irritation after 8 hour exposures to 200 ppm. No increase in red cell fragility was seen after these brief exposures. [ACGIH] For ethylene glycol ethers, there is limited positive evidence of spontaneous abortions and decreased sperm counts in humans and strong positive evidence of birth defects and testicular damage in animals. [ATSDR Case Studies # 29] Humans are resistant to butoxyethanol-induced red blood cell hemolysis. [Sullivan, p. 1204] See "Glycol ethers."

Reference Link

ATSDR - ToxFAQs - 2-Butoxyethanol

Exposure Assessment
BEI

Butoxyacetic acid (BAA) in urine = 200 mg/g creatinine at end of shift.

Skin Designation (ACGIH)

No

MAK

10 ppm

Excerpts from Documentation for IDLHs

Human data: It has been stated that humans would be able to tolerate saturated concentrations (i.e., about 1,000 ppm) for 1 hour without experiencing any significant nonreversible effects [Carpenter et al. 1956].

Vapor Pressure

0.8 mm Hg

Odor Threshold Low

0.1 ppm

Odor Threshold High

0.35 ppm

RD50

2824 ppm

Lethal Concentration

LC50 (rat)= 450 ppm/4hr;

Explanatory Notes

Detection odor threshold from AIHA (mean = 0.1 ppm); Flash point = 62 deg C;

Half Life

0.6 to 4.8 hours [Sullivan, p. 1203]

Reference Link

OECD SIDS: Monoethylene Glyco Ethers - 2004

Flammability (NFPA)

2: High ambient temperature required

Adverse Effects
Nephrotoxin

Yes

Reproductive Toxin

Yes

Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Secondary

IARC Carcinogen

Not Classifiable

ACGIH Carcinogen

Confirmed Animal

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Chemical Information

Search ChemIDplus

Biomedical References

Search PubMed

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure:

Activities

Activities with risk of exposure: