| Agent Name | Acetone |
|---|---|
| CAS Number | 67-64-1 |
| Formula | C3-H6-O |
| Major Category | Solvents |
| Synonyms | 2-Propanone; Aceton [German, Dutch, Polish]; Acetone; Acetone (natural); Chevron acetone; Dimethyl ketone; Dimethylformaldehyde; Dimethylketal; Ketone propane; Ketone, dimethyl; Methyl ketone; Propanone; Pyroacetic acid; Pyroacetic ether; beta-Ketopropane; [ChemIDplus] UN1090 |
| Category | Ketones (<C12) |
| Description | Colorless liquid with a fragrant, mint-like odor; [NIOSH] |
| Sources/Uses | Used as a solvent; used to produce methacrylates; [LaDou, p. 504] |
| Exposure Assessment | |
| BEI | Acetone in urine = 50 mg/L; end of shift; |
| Skin Designation (ACGIH) | Insufficient data |
| TLV (ACGIH) | 500 ppm |
| STEL (ACGIH) | 750 ppm |
| PEL (OSHA) | 1000 ppm |
| MAK | 500 ppm |
| IDLH (NIOSH) | 2500 ppm |
| Excerpts from Documentation for IDLHs | Volunteers experienced slight irritation at 300 ppm but 500 ppm was tolerated [Nelson et al. 1943]. Eye irritation, headache, lightheadedness, nasal irritation, and throat irritation were noted in workers exposed to concentrations considerably in excess of 1,000 ppm and perhaps as high as 6,500 ppm [Raleigh and McGee 1972]. No indications of toxicity were reported following exposures to 2,100 ppm for 8 hours/day [Haggard et al. 1944]. |
| Vapor Pressure | 232 mm Hg |
| Odor Threshold Low | 3.6 ppm |
| Odor Threshold High | 653 ppm |
| RD50 | 23480 ppm |
| Lethal Concentration | LC50 (rat) =50,100 mg/m3/8H |
| Explanatory Notes | IDLH 10% LEL (lower explosive limit; Detection odor threshold from AIHA (mean = 62 ppm); Flash point = -18 deg C; See 2012 Notice of Intended Changes. [TLVs and BEIs] |
| Half Life | Blood: 3 hours; whole body: 19-31 hours; [TDR, p. 17] |
| Reference Link | |
| Flammability (NFPA) | |
| Adverse Effects | |
| Neurotoxin | CNS Solvent Syndrome |
| Links to Other NLM Databases | |
| Health Studies | Human Health Effects from Hazardous Substances Data Bank: |
| Toxicity Information | |
| Chemical Information | |
| Biomedical References | |
| Related Information in HazMap | |
| Diseases | Occupational diseases associated with exposure to this agent: |
| Processes | Industrial Processes with risk of exposure: |
| Activities | Activities with risk of exposure: |
Agent Name
Acetone
CAS Number
67-64-1
Formula
C3-H6-O
Major Category
Solvents
Synonyms
2-Propanone; Aceton [German, Dutch, Polish]; Acetone; Acetone (natural); Chevron acetone; Dimethyl ketone; Dimethylformaldehyde; Dimethylketal; Ketone propane; Ketone, dimethyl; Methyl ketone; Propanone; Pyroacetic acid; Pyroacetic ether; beta-Ketopropane; [ChemIDplus] UN1090
Category
Ketones (<C12)
Description
Colorless liquid with a fragrant, mint-like odor; [NIOSH]
Sources/Uses
Used as a solvent; used to produce methacrylates; [LaDou, p. 504]
Exposure Assessment
BEI
Acetone in urine = 50 mg/L; end of shift;
Skin Designation (ACGIH)
Insufficient data
TLV (ACGIH)
500 ppm
STEL (ACGIH)
750 ppm
PEL (OSHA)
1000 ppm
MAK
500 ppm
IDLH (NIOSH)
2500 ppm
Excerpts from Documentation for IDLHs
Volunteers experienced slight irritation at 300 ppm but 500 ppm was tolerated [Nelson et al. 1943]. Eye irritation, headache, lightheadedness, nasal irritation, and throat irritation were noted in workers exposed to concentrations considerably in excess of 1,000 ppm and perhaps as high as 6,500 ppm [Raleigh and McGee 1972]. No indications of toxicity were reported following exposures to 2,100 ppm for 8 hours/day [Haggard et al. 1944].
Vapor Pressure
232 mm Hg
Odor Threshold Low
3.6 ppm
Odor Threshold High
653 ppm
RD50
23480 ppm
Lethal Concentration
LC50 (rat) =50,100 mg/m3/8H
Explanatory Notes
IDLH 10% LEL (lower explosive limit; Detection odor threshold from AIHA (mean = 62 ppm); Flash point = -18 deg C; See 2012 Notice of Intended Changes. [TLVs and BEIs]
Half Life
Blood: 3 hours; whole body: 19-31 hours; [TDR, p. 17]
Reference Link
Flammability (NFPA)
Adverse Effects
Neurotoxin
CNS Solvent Syndrome
Links to Other NLM Databases
Toxicity Information
Chemical Information
Biomedical References
Related Information in HazMap
Diseases
Occupational diseases associated with exposure to this agent:
Processes
Industrial Processes with risk of exposure: