Agent Name

Acetone

CAS Number

67-64-1

Formula

C3-H6-O

Major Category

Solvents

Synonyms

2-Propanone; Aceton [German, Dutch, Polish]; Acetone; Acetone (natural); Chevron acetone; Dimethyl ketone; Dimethylformaldehyde; Dimethylketal; Ketone propane; Ketone, dimethyl; Methyl ketone; Propanone; Pyroacetic acid; Pyroacetic ether; beta-Ketopropane; [ChemIDplus] UN1090

Category

Ketones (<C12)

Description

Colorless liquid with a fragrant, mint-like odor; [NIOSH]

Sources/Uses

Used as a solvent; used to produce methacrylates; [LaDou, p. 504]

Exposure Assessment
BEI

Acetone in urine = 50 mg/L; end of shift; See 2014 Notice of Intended Changes. [TLVs and BEIs]

Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

500 ppm

STEL (ACGIH)

750 ppm

PEL (OSHA)

1000 ppm

MAK

500 ppm

IDLH (NIOSH)

2500 ppm

Excerpts from Documentation for IDLHs

Volunteers experienced slight irritation at 300 ppm but 500 ppm was tolerated [Nelson et al. 1943]. Eye irritation, headache, lightheadedness, nasal irritation, and throat irritation were noted in workers exposed to concentrations considerably in excess of 1,000 ppm and perhaps as high as 6,500 ppm [Raleigh and McGee 1972]. No indications of toxicity were reported following exposures to 2,100 ppm for 8 hours/day [Haggard et al. 1944].

Vapor Pressure

232 mm Hg

Odor Threshold Low

3.6 ppm

Odor Threshold High

653 ppm

RD50

23480 ppm

Lethal Concentration

LC50 (rat) =50,100 mg/m3/8H

Explanatory Notes

IDLH 10% LEL (lower explosive limit; Detection odor threshold from AIHA (mean = 62 ppm); Flash point = -18 deg C; See 2014 Notice of Intended Changes. [TLVs and BEIs]

Half Life

Blood: 3 hours; whole body: 19-31 hours; [TDR, p. 17]

Reference Link

ATSDR - ToxFAQs - Acetone

Flammability (NFPA)

3: May ignite at ambient temperature

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

ACGIH Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Chemical Information

Search ChemIDplus

Biomedical References

Search PubMed

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure:

Activities

Activities with risk of exposure: