Agent Name

Dimethylformamide

CAS Number

68-12-2

Formula

C3-H7-N-O

Major Category

Solvents

Synonyms

DMF; DMF (amide); DMFA; Dimethyl formamide; Dimethylamid kyseliny mravenci [Czech]; Dimethylformamid [German]; Dimethylformamide; Dimetilformamide [Italian]; Dimetylformamidu [Czech]; Dwumetyloformamid [Polish]; Formamide, N,N-dimethyl-; Formic acid, amide, N,N-dimethyl-; N,N-Dimethyl formamide; N,N-Dimethylformamide; N,N-Dimethylmethanamide; N,N-Dimetilformamida [Spanish]; N-Formyldimethylamine; U-4224; [ChemIDplus] UN2265

Category

Amides (

Description

Colorless to pale-yellow liquid with a faint, amine-like odor; [NIOSH]

Sources/Uses

Used as a solvent in acrylic fiber spinning, textile dyeing, and paint stripping; also used in coating, printing, gluing, and pharmaceutical manufacturing; [http://www.cdc.gov/niosh/90-105.html] Used as a solvent for vinyl resins; [Kanerva, p. 1146] Used in synthetic leather manufacturing; [JOEM 2004;46:729-736]

Comments

Liquid causes first degree burns on short exposure; [CHRIS] Allergic contact dermatitis reported in epoxy resin handlers; [Kanerva, p. 1146] DMF is toxic to the liver. [Reference #1] May cause liver injury and jaundice; [ICSC] Animals exposed to single lethal doses have CNS depression, anesthesia, convulsions, and coma. [HSDB] In the list of 15 chemicals classified as potentially fetotoxic even if MAK value observed; [Reference #2]

Reference Link

Preventing Adverse Health Effects from Exposure to Dimethylformamide (DMF)

Exposure Assessment
BEI

N-Methylformamide in urine = 15 mg/L at end of shift;N-Acetyl-S-(N-Methylcarbamoyl)cysteine in urine = 40mg/L prior to last shift of workweek

Skin Designation (ACGIH)

Yes

TLV (ACGIH)

10 ppm

PEL (OSHA)

10 ppm

MAK

5 ppm

IDLH (NIOSH)

500 ppm

Excerpts from Documentation for IDLHs

Basis for original (SCP) IDLH: The chosen IDLH is based on the statements by Clayton et al. [1963] that rats survived a 4­hour exposure to air saturated with dimethylformamide vapor [Smyth and Carpenter 1948] and inhalation of saturated vapors for 6 hours was lethal [Haskell Laboratory]. A.D. Little reports that the saturated concentration at 20 C is 3,550 ppm. Because exposures to rats for 4 hours were at saturated concentrations, 3,500 ppm is chosen as the IDLH. . . . Human data: None relevant for use in determining the revised IDLH.

Vapor Pressure

3 mm Hg

Odor Threshold Low

0.47 ppm

Odor Threshold High

100 ppm

Lethal Concentration

LCLo (rat) = 5,000 ppm/6 hr

Explanatory Notes

Odor threshold from AIHA; Flash point = 58 deg C;

Half Life

Whole body: 4 hours; [TDR, p. 551]

Reference Link

Reproductive toxicology in occupational settings: ...[Int Arch Occup Environ Health. 2006] - PubMed Result

Flammability (NFPA)

2: High ambient temperature required

Adverse Effects
Reproductive Toxin

Yes

Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Primary

Dermatotoxin

Skin Burns

IARC Carcinogen

Not Classifiable

ACGIH Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Chemical Information

Search ChemIDplus

Biomedical References

Search PubMed

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: