| Agent Name | Tetrachlorodibenzo-p-dioxin |
|---|---|
| CAS Number | 41903-57-5 |
| Formula | C12-H4-Cl4-O2 |
| Major Category | Other Classes |
| Synonyms | Tetrachlorodibenzo(b,e)(1,4)dioxin; [ChemIDplus] 1,2,6,7-Tetrachlorodibenzo-p-dioxin; [MSDSonline] |
| Category | Halogenated Polyaromatics |
| Description | White powder; [MSDSonline] |
| Sources/Uses | Produced from combustion of coal, refuse, wood, cigarettes, and materials containing PVC; Also found in municipal waste water and effluents from pulp and paper manufacture (when chlorine used for bleaching); Not commercially produced; [HSDB] |
| Comments | There are 22 possible isomers; IARC classification for 2,3,7,8-Tetrachlorodibenzo-para-dioxin is "known" and for other isomers is " not classifiable"; Polychlorodibenzodioxins have caused chloracne in humans; 2,3,7,8-Tetrachlorodibenzodioxin is the most toxic of the polychlorodibenzodioxins tested so far in animals; Transferred to infants in breast milk; No increased birth defects in persons exposed in Seveso incident; All Seveso patients with severe chloracne had TCDD levels >12,000 ppt; [HSDB] See "2,3,7,8-Tetrachlorodibenzo-p-dioxin." |
| Exposure Assessment | |
| Vapor Pressure | 5.9e-11 mm Hg |
| Adverse Effects | |
| Reproductive Toxin | Yes |
| Hepatotoxin | Hepatotoxin, Secondary |
| Dermatotoxin | Chloracne |
| IARC Carcinogen | Not Classifiable |
| Links to Other NLM Databases | |
| Health Studies | Human Health Effects from Hazardous Substances Data Bank: |
| Toxicity Information | |
| Chemical Information | |
| Related Information in HazMap | |
| Diseases | Occupational diseases associated with exposure to this agent: |
Agent Name
Tetrachlorodibenzo-p-dioxin
CAS Number
41903-57-5
Formula
C12-H4-Cl4-O2
Major Category
Other Classes
Synonyms
Tetrachlorodibenzo(b,e)(1,4)dioxin; [ChemIDplus] 1,2,6,7-Tetrachlorodibenzo-p-dioxin; [MSDSonline]
Category
Halogenated Polyaromatics
Description
White powder; [MSDSonline]
Sources/Uses
Produced from combustion of coal, refuse, wood, cigarettes, and materials containing PVC; Also found in municipal waste water and effluents from pulp and paper manufacture (when chlorine used for bleaching); Not commercially produced; [HSDB]
Comments
There are 22 possible isomers; IARC classification for 2,3,7,8-Tetrachlorodibenzo-para-dioxin is "known" and for other isomers is " not classifiable"; Polychlorodibenzodioxins have caused chloracne in humans; 2,3,7,8-Tetrachlorodibenzodioxin is the most toxic of the polychlorodibenzodioxins tested so far in animals; Transferred to infants in breast milk; No increased birth defects in persons exposed in Seveso incident; All Seveso patients with severe chloracne had TCDD levels >12,000 ppt; [HSDB] See "2,3,7,8-Tetrachlorodibenzo-p-dioxin."
Exposure Assessment
Vapor Pressure
5.9e-11 mm Hg
Adverse Effects
Reproductive Toxin
Yes
Hepatotoxin
Hepatotoxin, Secondary
Dermatotoxin
Chloracne
IARC Carcinogen
Not Classifiable
Links to Other NLM Databases
Toxicity Information
Chemical Information
Related Information in HazMap