Agent Name

Tetrachlorodibenzo-p-dioxin

CAS Number

41903-57-5

Formula

C12-H4-Cl4-O2

Major Category

Other Classes

Synonyms

Tetrachlorodibenzo(b,e)(1,4)dioxin; [ChemIDplus] 1,2,6,7-Tetrachlorodibenzo-p-dioxin; [MSDSonline]

Category

Halogenated Polyaromatics

Description

White powder; [MSDSonline]

Sources/Uses

Produced from combustion of coal, refuse, wood, cigarettes, and materials containing PVC; Also found in municipal waste water and effluents from pulp and paper manufacture (when chlorine used for bleaching); Not commercially produced; [HSDB]

Comments

There are 22 possible isomers; IARC classification for 2,3,7,8-Tetrachlorodibenzo-para-dioxin is "known" and for other isomers is " not classifiable"; Polychlorodibenzodioxins have caused chloracne in humans; 2,3,7,8-Tetrachlorodibenzodioxin is the most toxic of the polychlorodibenzodioxins tested so far in animals; Transferred to infants in breast milk; No increased birth defects in persons exposed in Seveso incident; All Seveso patients with severe chloracne had TCDD levels >12,000 ppt; [HSDB] See "2,3,7,8-Tetrachlorodibenzo-p-dioxin."

Exposure Assessment
Vapor Pressure

0.000000000059 mm Hg

Adverse Effects
Reproductive Toxin

Yes

Hepatotoxin

Hepatotoxin, Secondary

Dermatotoxin

Chloracne

IARC Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: