Agent Name

Tetrachlorodibenzo-p-dioxin

CAS Number

41903-57-5

Formula

C12-H4-Cl4-O2

Major Category

Other Classes

Synonyms

Tetrachlorodibenzo(b,e)(1,4)dioxin; [ChemIDplus] 1,2,6,7-Tetrachlorodibenzo-p-dioxin; [MSDSonline]

Category

Halogenated Polyaromatics

Description

White powder; [MSDSonline]

Sources/Uses

Produced from combustion of coal, refuse, wood, cigarettes, and materials containing PVC; Also found in municipal waste water and effluents from pulp and paper manufacture (when chlorine used for bleaching); Not commercially produced; [HSDB]

Comments

There are 22 possible isomers; IARC classification for 2,3,7,8-Tetrachlorodibenzo-para-dioxin is "known" and for other isomers is " not classifiable"; Polychlorodibenzodioxins have caused chloracne in humans; 2,3,7,8-Tetrachlorodibenzodioxin is the most toxic of the polychlorodibenzodioxins tested so far in animals; Transferred to infants in breast milk; No increased birth defects in persons exposed in Seveso incident; All Seveso patients with severe chloracne had TCDD levels >12,000 ppt; [HSDB] See "2,3,7,8-Tetrachlorodibenzo-p-dioxin."

Exposure Assessment
Vapor Pressure

5.9e-11 mm Hg

Adverse Effects
Reproductive Toxin

Yes

Hepatotoxin

Hepatotoxin, Secondary

Dermatotoxin

Chloracne

IARC Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: