Agent Name

Thimerosal

CAS Number

54-64-8

Formula

C9-H9-Hg-O2-S.Na

Major Category

Other Uses

Synonyms

Collyrium Eye Wash; ((o-Carboxyphenyl)thio)ethylmercury sodium salt; Aeroaid spray; Elcide 73; Elcide 75; Elicide; Estivin; Ethyl (sodium o-mercaptobenzoato)mercury; Ethyl(2-mercaptobenzoato-S)mercury sodium salt; Ethylmercurithiosalicyclic acid, sodium salt; Ethylmercurithiosalicylate sodium; Ethylmercurithiosalicylate sodium salt; Ethylmercurithiosalicylic acid sodium salt; Ethylmerkurithiosalicilan sodny [Czech]; Mercurate(1-), ethyl(2-mercaptobenzoate(2-)-O,S)-, sodium; salt; Mercurate(1-), ethyl(o-mercaptobenzoato(2-))-, sodium; Mercurothiolate; Mercurothiolatum; Mercury, ((o-carboxyphenyl)thio)ethyl-, sodium salt; Mercury, ethyl(2-mercaptobenzoate-S)-, sodium salt; Mercury, ethyl(2-mercaptobenzoato-S)-, sodium salt; Merfamin; Merphol; Merseptyl (VAN); Merthiolate; Merthiolate salt; Merthiolate sodium; Mertorgan; Merzonin; Merzonin sodium; Nosemack; SET; Sodium 2-(ethylmercurithio)benzoate; Sodium ethylmercuric thiosalicylate; Sodium ethylmercurithiosalicylate; Sodium merthiolate; Sodium o-(ethylmercurithio)benzoate; Thimerosal; Thimerosalate; Thimerosalum; Thimerosol; Thimersalate; Thiomersal; Thiomersalat; Thiomersalate; Thiomersalum [INN-Latin]; Tiomersal [INN-Spanish]; Tiomersale [DCIT]; Vitaseptol Loesung; o-(Ethylmercurithio)benzoic acid sodium salt; [ChemIDplus] UN2025

Category

Preservatives

Description

Light cream-colored crystalline powder with a slight odor; [CAMEO]

Sources/Uses

Used as a preservative in eye drops, vaccines, and cleaners for contact lenses; [Kanerva, p. 1173] Used in vaccines until 1999 at a concentration of 25 ug per 0.5 ml dose of several common vaccines; [Rom, p. 992] Has been removed from US-licensed vaccines for children under 7 years--either thimerosal-free or contain only trace amounts (<0.5 ug Hg/dose) with the exception of some inactivated influenza vaccines. [Goldfrank, p. 812]

Comments

Allergic contact dermatitis reported in a medical assistant (ophthalmology) and in veterinarians; [Kanerva, p. 1173] Thimerosal is metabolized to ethylmercury and thiosalicylate. [Rom, p. 992] See "Mercury, aryl compounds" and the linked diseases.

Reference Link

Occupational contact dermatitis of the eyelids, without ocular involvement, from thimerosal in contact lens fluid

Exposure Assessment
Skin Designation (ACGIH)

Yes

TLV (ACGIH)

0.1 mg/m3, as Hg

PEL (OSHA)

0.1 mg/m3, as Hg

IDLH (NIOSH)

10 mg/m3, as Hg

Reference Link

Occupational dermatitis in veterinarians

Adverse Effects
Skin Sensitizer

Yes

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: