Agent Name

Nitrogen mustard (HN-2)

Alternative Name

Mechlorethamine

CAS Number

51-75-2

Formula

C5-H11-Cl2-N

Major Category

Toxic Gases & Vapors

Synonyms

Mechlorethamine; Bis(beta-chloroethyl)methylamine; N,N-Bis(2-chloroethyl)methylamine; Bis(2-chloroethyl)methylamine; Caryolysine; Chloramine (the Nitrogen Mustard); Chlorethazine; Chlormethine; 2-Chloro-N-(2-chloroethyl)-N-methylethanamine; Dichlor Amine; Dichloren (German); Beta,beta'-Dichlorodiethyl-N-methylamine; Di(chloroethyl)methylamine; N,N-Di(chloroethyl)methylamine; Di(2-chloroethyl)methylamine; 2,2'-Dichloro-N-methyldiethylamine; Diethylamine, 2,2'-dichloro-N-methyl-; Embichin; Ethanamine, 2-Chloro-N-(2-chloroethyl)-N-methyl-; HN2; HN-2; N-Methyl-Lost (German); N-Methyl-bis-chloraethylamin (German); Methylbis(chloroethylamine); Methylbis(beta-chloroethyl)amine; N-Methylbis(beta-chloroethyl)amine; N-Methylbis(2-chloroethyl)amine; Methylbis(2-chloroethyl)amine; N-Methyl-2,2'-dichlorodiethylamine; Methyldi(2-chloroethyl)amine; Mustargen; Mustine; Nitrogen mustard; Stickstofflost (ebewe); TL 146; [HSDB]

Category

Chemical Weapons

Description

Colorless to pale yellow, oily liquid with a faint soapy odor or fruity odor at high concentrations; [ATSDR-MMG]

Sources/Uses

Used as an antineoplastic drug and formerly used as a gas warfare agent; [HSDB]

Comments

"Nitrogen mustards are vesicants causing skin, eye, and respiratory tract injury. Although these agents cause cellular changes within several minutes of contact, the onset of pain and other clinical effects is delayed for hours. Nitrogen mustards are alkylating agents that may cause bone marrow suppression and neurologic toxicity. . . . Nitrogen mustards may decrease fertility." [ATSDR MMG] "Germ cell mutagens that have shown to increase the mutant frequency in the progeny of exposed mammals." [MAK]

Reference Link

ATSDR - Medical Management: Nitrogen Mustard

Exposure Assessment
TIH

Yes

Vapor Pressure

0.42 mm Hg

Explanatory Notes

Danger of sensitization of skin; [MAK] LCt50 = 3,000 mg-min/m; [ATSDR MMG] TIH when used as a weapon; [ERG 2012]

Adverse Effects
Reproductive Toxin

Yes

Toxic Pneumonitis

Yes

Neurotoxin

Other CNS Neurotoxin

Anemia

Anemia, Aplastic

Dermatotoxin

Skin Burns

IARC Carcinogen

Probable Carcinogen

NTP Carcinogen

Anticipated Human Carcinogen

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Chemical Information

Search ChemIDplus

Biomedical References

Search PubMed

Related Information in HazMap
Other Information

No other related information on this agent was found.