Agent Name

Nitrogen mustard (HN-3)

Alternative Name

Tris(2-chloroethyl)amine

CAS Number

555-77-1

Formula

C6-H12-Cl3-N

Major Category

Toxic Gases & Vapors

Synonyms

Tris(2-chloroethyl)amine; 2,2',2''-Trichlorotriethylamine; 2-Chloro-N,N-bis(2-chloroethyl)ethanamine; A 8729; Agent HN3; Ethanamine, 2-chloro-N,N-bis(2-chloroethyl)-; HN-3; HN3; Sinalost base; TL 145; TS 160; Tri-(2-chloroethyl)amine; Trichlormethinum [INN-Latin]; Triclormetina [INN-Spanish]; Triethylamine, 2,2',2"-trichloro-; Trimitan base; Trimustine; Tris(beta-chloroethyl)amine; UN 2810; [ChemIDplus]

Category

Chemical Weapons

Description

Colorless to pale yellow, oily liquid with a faint butter almond odor; [ATSDR-MMG]

Sources/Uses

Used in medicine as an antineoplastic drug; A vesicant that has not been used as a chemical weapon; [HSDB]

Comments

"Nitrogen mustards are vesicants causing skin, eye, and respiratory tract injury. Although these agents cause cellular changes within several minutes of contact, the onset of pain and other clinical effects is delayed for hours. Nitrogen mustards are alkylating agents that may cause bone marrow suppression and neurologic toxicity. . . . Nitrogen mustards may decrease fertility." [ATSDR MMG]

Reference Link

ATSDR - Medical Management: Nitrogen Mustard

Exposure Assessment
Vapor Pressure

0.01 mm Hg

Explanatory Notes

LCt50 = 1,500 mg-min/m; [ATSDR-MMG]

Adverse Effects
Reproductive Toxin

Yes

Toxic Pneumonitis

Yes

Neurotoxin

Other CNS Neurotoxin

Anemia

Anemia, Aplastic

Dermatotoxin

Skin Burns

IARC Carcinogen

Probable Carcinogen

NTP Carcinogen

Anticipated Human Carcinogen

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Chemical Information

Search ChemIDplus

Related Information in HazMap
Other Information

No other related information on this agent was found.