Agent Name

Acetylsalicylic acid

Alternative Name

Aspirin

CAS Number

50-78-2

Formula

C9-H8-O4

Major Category

Other Uses

Synonyms

Acesal; o-Acetoxybenzoic acid; 2-Acetoxybenzoic acid; Aspirin

Category

Pharmaceuticals

Description

Odorless, colorless to white, crystal-line powder. [aspirin] [Note: Develops the vinegar-like odor of acetic acid on contact with moisture.]

Comments

Acetylsalicylic acid can cause contact urticaria. [Kanerva 2004, p. 98] Aspirin poisoning was one of the leading causes of accidental death in children until child-proof bottles were developed; After ingestion, causes stimulation of respiratory center in brain and metabolic acidosis; Prolongs prothrombin time and complicated by cerebral and pulmonary edema; 1 aspirin tablet = 325-650 mg acetylsalicylic acid; 1 teaspoon concentrated oil of wintergreen = 5 g of methyl salicylate (equivalent to 7.5 g of acetylsalicylic acid); Acute ingestion of 150-200 mg/kg aspirin = mild intoxication; Acute ingestion of 300-500 mg/kg aspirin = severe intoxication; [Olson, p. 363-4]

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

5 mg/m3

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Chemical Information

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Diseases

Occupational diseases associated with exposure to this agent: