Agent Name

Chlordane

CAS Number

57-74-9

Formula

C10-H6-Cl8

Major Category

Pesticides

Synonyms

Chlordan; Clordano; 1,2,4,5,6,7,8,8-Octachloro-3a,4,7,7a-tetrahydro-4,7-methanoindane; [NIOSH] Chlor-Kil; Dowchlor; Gold Crest C-100; Octa-Klor; Topiclor 20; Velsicol 1068; [ATSDR Case Studies] BELT; Chlor Kil; Chlortox; Corodane; Gold Crest C-100; Kilex Lindane; Kypchlor; Niran; Octachlor; Synklor; Termex; Topiclor 20; Toxichlor; Velsicol 1068; [EXTOXNET]

Category

Organochlorine Pesticides

Description

Amber-colored, viscous liquid with a pungent, chlorine-like odor. [insecticide]; [NIOSH]

Sources/Uses

Formerly used as an insecticide and fumigant; Formulations available internationally for termite control and wood treatment; [HSDB]

Comments

Classified as "moderately toxic," it persists in soil with a half-life of about 4 years. In two cases of poisoning by ingestion, the biological half-life of chlordane in serum was found to be 88 days and 21 days. [EXTOXNET] High-dose animal studies show that organochlorine insecticides can cause liver injury. [LaDou, p. 553] "No evidence of hepatic injury in humans as the result of environmental contamination." [Zimmerman, p. 414]

Restricted

EPA banned it for food crops in 1978 and for termite control in 1988. Chlordane is still licensed for fire ant control in electric transformers. [EXTOXNET] All U.S. registrations cancelled; [EPA Pesticides, p. 56]

Reference Link

EXTOXNET PIP - CHLORDANE

Exposure Assessment
Skin Designation (ACGIH)

Yes

Bioaccumulates

Yes

MAK

0.5 mg/m3

Excerpts from Documentation for IDLHs

Human data: The fatal oral dose has been estimated to be about 6 grams [Derbes et al. 1955] or to range from 6 to 60 grams [Pennsylvania 1969]. [Note: An oral dose of 6 grams is equivalent to a worker being exposed to about 4,000 mg/m3 for 30 minutes, assuming a breathing rate of 50 liters per minute and 100% absorption.]

Vapor Pressure

1e-05 mm Hg

Half Life

An "extended period of time" because of accumulation in fat; [TDR, p. 302] See "Comments."

Reference Link

ATSDR Medical Management - Chlordane

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Other Poison

Organochlorine Pesticide

IARC Carcinogen

Possible Carcinogen

ACGIH Carcinogen

Confirmed Animal

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Chemical Information

Search ChemIDplus

Biomedical References

Search PubMed

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: