Agent Name

Eugenol

CAS Number

97-53-0

Formula

C10-H12-O2

Major Category

Biological Agents

Synonyms

2-Methoxy-4-(2-propenyl)phenol; 1,3,4-Eugenol; 1-Hydroxy-2-methoxy-4-allylbenzene; 1-Hydroxy-2-methoxy-4-prop-2-enylbenzene; 1-Hydroxy-2-methoxy-4-propenylbenzene; 2-Methoxy-1-hydroxy-4-allylbenzene; 2-Methoxy-4-(2-propen-1-yl)phenol; 2-Methoxy-4-allylphenol; 2-Methoxy-4-prop-2-enylphenol; 2-Metoksy-4-allilofenol [Polish]; 4-Allyl-1-hydroxy-2-methoxybenzene; 4-Allyl-2-methoxyphenol; 4-Allylcatechol 2-methyl ether; 4-Allylcatechol-2-methyl ether; 4-Allylguaiacol; 4-Hydroxy-3-methoxy-1-allylbenzene; 4-Hydroxy-3-methoxyallylbenzene; 5-Allylguaiacol; Allylguaiacol; Caryophyllic acid; Eugenic acid; Eugenol (natural); FA 100; Phenol, 2-methoxy-4-(2-propenyl)-; Phenol, 4-allyl-2-methoxy-; Synthetic eugenol; p-Allylguaiacol; p-Eugenol; Phenol, 2-methoxy-4-(2-propen-1-yl)-; [ChemIDplus]

Category

Plant-Derived Allergens

Description

Colorless to pale yellow liquidwith an odor of cloves; Darkened and thickened by air; [Merck Index] Colorless, light yellow, or amber liquid; [CAMEO]

Sources/Uses

A fragrance and spice derived from the oil of cloves; used in cosmetics, over-the-counter drugs, toothpastes, and foods; [Marks, p. 172-3] From numerous natural sources and the main active ingredient in cloves; Used in perfumery, flavoring, manufacture of vanillin, medicine (germicide and in over the counter drugs), dentistry (analgesic, root canal disinfectant, and in cements and other materials); Also used as an insect attractant, chemical intermediate, and denaturant for alcohol; Has been used as fungicide in pharmaceuticals and cosmetics, as antiputrescent, and to treat flatulent colic; [HSDB] Active ingredient in consumer insecticides and Japanese beetle baits/traps; [NPIRS]

Comments

A contact skin allergen present in cosmetics and foods; [Marks, p. 172] Occupational asthma confirmed in a hairdresser; [Malo] Toxic by ingestion: metabolic acidosis, proteinuria, hepatotoxicity, CNS depression, ataxia, and convulsions; [HSDB] Generally regarded as safe (GRAS) for use in foods; [FDA] A primary irritant; May cause skin sensitization and contact dermatitis; [CAMEO] Safe when used as a flavoring agent in food; Acceptable daily intake (ADI) of 0-2.5 mg/kg; [JECFA] Mildly irritating to human skin; [RTECS]

Reference Link

Occupational asthma and rhinitis caused by eugenol in a hairdresser

Exposure Assessment
Vapor Pressure

0.01 mm Hg

Lethal Concentration

LC50 > 2,580 mg/m3/4hr

Flammability (NFPA)

2: High ambient temperature required

Adverse Effects
Skin Sensitizer

Yes

Asthma

Yes

Neurotoxin

Other CNS Neurotoxin

Hepatotoxin

Hepatotoxin, Secondary

IARC Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

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Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: