Agent Name

Bisphenol A-glycidyl methacrylate

Alternative Name

BIS-GMA

CAS Number

1565-94-2

Formula

C29-H36-O8

Major Category

Plastics & Rubber

Synonyms

BIS-BMA; 2-Propenoic acid, 2-methyl-, (1-methylethylidene)bis(4,1-phenyleneoxy(2-hydroxy-3,1-propanediyl)) ester; Bis-gma; Bisphenol A glycidylmethacrylate; Bisphenol A-diglycidyl-dimethyl acrylate; Bisphenol(a)glycidylmethacrylate; Nupol 1629; Nupol 46-4005; (1-Methylethylidene)bis(4,1-phenyleneoxy(2-hydroxy-3,1-propanediyl)) bismethacrylate; 2-Propenoic acid, 2-methyl-, 1,1'-((1-methylethylidene)bis(4,1-phenyleneoxy(2-hydroxy-3,1-propanediyl))) ester; [ChemIDplus]

Category

(Meth)acrylates

Description

Liquid; [Aldrich MSDS]

Sources/Uses

Allergic contact dermatitis in dental workers; [Marks] The reaction product of bisphenol A and glycidyl methacrylate that is polymerized by UV light or a catalyst; Used as bond implant material and as the resin component of dental sealants and composite restorative materials; [ChemIDplus] "Dental composite resins, UV-curable printing inks, and some glues contain epoxy acrylates such as bis-GMA and bis-GA." [Kanerva, p. 543] Bis-GMA was first developed in the 1960s as the first epoxy methacrylate for dental composite resins. [Kanerva, p. 546]

Comments

"Allergic contact dermatitis from acrylic resins typically affects the fingertips." [Kanerva, p. 543-9] Causes allergic dermatitis on topical exposure to human skin; Causes weight loss and changes in ovarian weight in 28-day intermittent oral study of mice; [RTECS] Unstable and sensitive to heat and light; May polymerize; An irritant; May cause serious eye injury; [Aldrich MSDS]

Reference Link

Allergic contact dermatitis to bisphenol-A-glycidyldimethacrylate (BIS-GMA) dental resin associated with sensitivity to epoxy resin

Adverse Effects
Skin Sensitizer

Yes

Links to Other NLM Databases
Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: