Agent Name

4,6-Dinitro-o-sec-butyl phenol

Alternative Name

Dinoseb

CAS Number

88-85-7

Formula

C10-H12-N2-O5

Major Category

Pesticides

Synonyms

Dinoseb; 2,4-Dinitro-6-(1-methylpropyl)phenol; 2,4-Dinitro-6-sec-butylphenol; 2-(1-Methylpropyl)-4,6-dinitrophenol; 2-sec-Butyl-4,6-dinitrophenol; 4,6-Dinitro-2-(1-methyl-n-propyl)phenol; 4,6-Dinitro-2-(1-methyl-propyl)phenol; 4,6-Dinitro-2-sec-butylphenol; 4,6-Dinitro-2-sec.butylfenol [Czech]; 6-(1-Methyl-propyl)-2,4-dinitrofenol [Dutch]; 6-(1-Metil-propil)-2,4-dinitro-fenolo [Italian]; Aatox; BNP 20; BNP 30; Basanite; Blaartox; Butaphen; Butaphene; Caldon; Chemox P.E.; Chemox General; Chemox PE; DBNF; DN 289; DNBP; DNOSBP; DNSBP; Desicoil; Dibutox; Dibutox 20CE; Dinitrall; Dinitro-ortho-sec-butyl phenol; Dinitrobutylphenol; Dinosebe [French]; Dinosebe [ISO-French]; Dow General; Dow General Weed Killer; Dow Selective Weed Killer; Dytop; Elgetol 318; Gebutox; knox-weed; Hel-Fire; Hivertox; Kiloseb; Knox-weed; Ladob; Laseb; Liro DNBP; Nitropone C; Phenol, 2-(1-methylpropyl)-4,6-dinitro-; Phenotan; Premerge; Sparic; Spurge; Subitex; Unicrop DNBP; Vertac Dinitro Weed Killer; Vertac General Weed Killer; Vertac Selective Weed Killer; WSX 8365; Phenol, 2-sec-butyl-4,6-dinitro-; [ChemIDplus] Aretit; Fanicide; HOE 26150; Ivosit; Knowx-Weed; Persevtox; Sinox General; [ICSC]

Category

Herbicides, Nitroaromatic

Description

Orange or yellow solid with a pungent odor; [HSDB]

Sources/Uses

Consumption patterns in 1986: 40% for soybeans; 16% for peanuts; 15% for potatoes; also used for alfalfa, snap beans, peas, grapes, and almonds; [HSDB] Used as herbicide, insecticide, and miticide; [Merck Index]

Comments

The pathophysiology, like that of pentachlorophenol, involves the uncoupling of oxidative phosphorylation. Yellow stains appear on the skin after dermal contact with the nitroaromatic herbicides. Fatal poisoning can occur after dermal absorption. Cataracts have been reported in animal experiments and after occupational exposure. In severe poisoning, these herbicides can cause injury to the liver and kidneys. [EPA Pesticides, p. 104-5] An eye irritant; Can be absorbed through skin; Short-term exposure may have effects on the GI tract and CNS; Prolonged or repeated exposure may affect the kidneys, liver, blood, immune system, and eyes (cataract); Aerosol exposure in hot environments may result in death; May be a reproductive toxicant in humans; [ICSC] A powerful oxidizing agent and explosive; Extremely toxic (enhanced by high ambient temperature and physical activity); [CAMEO]

Restricted

All uses cancelled in the U.S. in 1986; [EXTOXNET]

Reference Link

EXTOXNET - Dinoseb

Exposure Assessment
Reference Link

ATSDR - ToxFAQs - Dinitrophenols

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Nephrotoxin

Yes

Reproductive Toxin

Yes

Other Poison

Uncoupler

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: