Agent Name

3-Chloroaniline

Alternative Name

m-Chloroaniline

CAS Number

108-42-9

Formula

C6-H6-Cl-N

Major Category

Nitrogen Compounds

Synonyms

m-Chloroaniline; 1-Amino-3-chlorobenzene; 3-Chlooranilinen [Dutch]; 3-Chloroaniline; 3-Chlorobenzenamine; 3-Chlorophenylamine; 3-Cloroaniline [Italian]; AI3-12126; Aniline, m-chloro-; Benzenamine, 3-chloro-; Fast Orange GC Base; Orange GC Base; m-Aminochlorobenzene; m-Chloraniline; m-Chloroaminobenzene; m-Chloroaniline; m-Chlorophenylamine; meta-Aminochlorobenzene; [ChemIDplus] UN2019

Category

Amines, Aromatic

Description

Colorless to light amber, tends to darken during storage; [HSDB]

Sources/Uses

Used as an intermediate to produce herbicides, pharmaceuticals, azo dyes, and pigments; [HSDB]

Comments

"In the United Kingdom between 1961 and 1980, chloroaniline, p-toluidine, nitrobenzene, and nitrochlorobenzene were the most common industrial causes of methemoglobinemia. Dermal exposure was a more frequent route of toxicity than inhalation with these compounds." (Ellenhorn, M.J. and D.G. Barceloux. Medical Toxicology - Diagnosis and Treatment of Human Poisoning. New York, NY: Elsevier Science Publishing Co., Inc. 1988.) A skin and eye irritant; Can induce methemoglobinemia; [ICSC] Danger of skin sensitization; [MAK]

Exposure Assessment
BEI

Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH]

Vapor Pressure

0.05 mm Hg

Lethal Concentration

LC50 (mice) = 550 mg/m3/4h

Explanatory Notes

Flash point = 255 deg F;

Reference Link

EPA Pesticide Chemical Search

Adverse Effects
Skin Sensitizer

Yes

Methemoglobinemia

Methemoglobinemia, Primary

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: