Agent Name

Propionaldehyde

CAS Number

123-38-6

Formula

C3-H6-O

Major Category

Other Classes

Synonyms

Aldehyde propionique [French]; Methylacetaldehyde; PROPIONALDEHYDE; Propaldehyde; Propanal; Propanaldehyde; Propional; Propionaldehyde (natural); Propionic aldehyde; Propyl aldehyde; Propylaldehyde; Propylic aldehyde; n-Propanal; [ChemIDplus] UN1275

Category

Aldehydes

Description

Liquid with a suffocating odor; [Merck Index] Clear colorless liquid with an overpowering fruity odor; [CAMEO]

Sources/Uses

Used to make propionic acid, trimethylolethane, polyvinyl and other plastics, and rubber, medicinal, and agricultural chemicals; Also used as a disinfectant, preservative, and flavoring agent; [HSDB] Used as a chemical intermediate in closed systems and not contained in consumer products; [AIHA] Used almost exclusively (thought to be >99%) as a closed system intermediate and transported by bulk carrier; [OECD SIDS]

Comments

If left on clothing, can cause reddening of skin; [CHRIS] Propionaldehyde is a skin irritant. [Quick CPC] May form explosive peroxides; Vapor is irritating to eyes and respiratory tract; A severe skin and eye irritant; [ICSC] Causes pulmonary edema in lethal concentration studies in animals; [AIHA] Vapors (and peroxides that may be produced) are explosive; May vigorously polymerize; Vapors cause nose and throat irritation and may cause nausea and vomiting; An eye irritant; [CAMEO] Causes eye and respiratory tract irritation in humans at 14-16 mg/m3; Inhalation of 1,300 ppm for 6 days caused liver damage in rats; [HSDB] Safe when used as a flavoring agent in food; [JECFA] No specific adverse effects observed to reproduction or developing offspring in experimental animals; [OECD SIDS] See "ALDEHYDES."

Exposure Assessment
Skin Designation (ACGIH)

No

TLV (ACGIH)

20 ppm

WEEL

20 ppm

Vapor Pressure

317 mm Hg

RD50

2070 ppm

Lethal Concentration

LCLo (rat) = 8,000 ppm/4hr

Explanatory Notes

Flash point = -30 deg C (closed cup); VP = 235 mm Hg at 20 deg C; [ICSC]

Flammability (NFPA)

3: May ignite at ambient temperature

Adverse Effects
Toxic Pneumonitis

Yes

Hepatotoxin

Hepatotoxin, Secondary

Links to Other NLM Databases
Health Studies

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Toxicity Information

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Processes

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