Agent Name

2-Chloroaniline

Alternative Name

o-Chloroaniline

CAS Number

95-51-2

Formula

C6-H6-Cl-N

Major Category

Nitrogen Compounds

Synonyms

1-Amino-2-chlorobenzene; 2-Chloroaniline; 2-Chlorobenzenamine; 2-Chlorophenylamine; Aniline, o-chloro-; Benzenamine, 2-chloro-; Fast Yellow GC Base; o-Aminochlorobenzene; o-Chloraniline; o-Chloroaminobenzene; o-Chloroaniline; [ChemIDplus] UN2019

Category

Amines, Aromatic

Description

Clear amber liquid with an amine odor; [CAMEO]

Sources/Uses

Used as an intermediate for dyes, pesticides, and rubber chemicals; [HSDB]

Comments

o-Chloroaniline is listed in a table "Examples of Industrial Chemicals for Which Methemoglobin Formation is the Principal Cause of Toxicity"; [ACGIH] "In the United Kingdom between 1961 and 1980, chloroaniline, p-toluidine, nitrobenzene, and nitrochlorobenzene were the most common industrial causes of methemoglobinemia. Dermal exposure was a more frequent route of toxicity than inhalation with these compounds." (Ellenhorn, M.J. and D.G. Barceloux. Medical Toxicology - Diagnosis and Treatment of Human Poisoning. New York, NY: Elsevier Science Publishing Co., Inc. 1988.) An eye irritant; Can induce methemoglobinemia; [ICSC] Negative results for skin sensitizer from guinea pig testing; [Reference #2]

Exposure Assessment
BEI

Methemoglobin in blood = 1.5% of hemoglobin during or end of shift

Vapor Pressure

0.2 mm Hg

Lethal Concentration

LC50 (rat) = 797 ppm/4h

Explanatory Notes

Flash point = 103 deg C;

Reference Link

EPA Pesticide Chemical Search

Adverse Effects
Methemoglobinemia

Methemoglobinemia, Primary

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: