Agent Name

Dichloroaniline, mixed isomers

CAS Number

27134-27-6

Formula

C6-H5-Cl2-N

Major Category

Nitrogen Compounds

Synonyms

Ar,ar-dichlorobenzenamine; [ChemIDplus] UN1590

Category

Amines, Aromatic

Description

Fine, light-tan crystals (3,4-dicloroaniline)

Sources/Uses

3,4-Dichloroaniline is used as an intermediate in the production of dyes and herbicides (diuron and propanil); [HSDB]

Comments

Listed in a table of "Industrial Chemicals for Which Methemoglobin Formation is the Principal Cause of Toxicity"; [ACGIH] Contaminants of 3,4-dichloroaniline can induce chloracne; [Rosenstock, p. 714] Some workers exposed to 3,4-dichloroaniline during the production of diuron, a herbicide, developed chloracne and elevation of liver function test results. [HSDB]

Exposure Assessment
BEI

Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH]

Bioaccumulates

Yes

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Methemoglobinemia

Methemoglobinemia, Primary

Dermatotoxin

Chloracne

Links to Other NLM Databases
Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: