Agent Name

o-Nitrochlorobenzene

Alternative Name

o-Chloronitrobenzene

CAS Number

88-73-3

Formula

C6-H4-Cl-N-O2

Major Category

Nitrogen Compounds

Synonyms

1-Chloro-2-nitrobenzene; 1-Nitro-2-chlorobenzene; 2-Chloro-1-nitrobenzene; 2-Chloronitrobenzene; 2-Nitrochlorobenzene; ONCB; o-Chloronitrobenzene; o-Nitrochlorobenzene; [ChemIDplus] UN1578

Category

Nitros, Aromatic

Description

Yellow crystals with an aromatic odor; [CAMEO]

Sources/Uses

"Used as an intermediate in the manufacture of o-aminophenol (used as a developer in the photography industry); [HDSB]

Comments

Crystals may cause severe skin burns. [HSDB] Listed in a table of "Industrial Chemicals for Which Methemoglobin Formation is the Principal Cause of Toxicity"; [ACGIH] "In the United Kingdom between 1961 and 1980, chloroaniline, p-toluidine, nitrobenzene, and nitrochlorobenzene were the most common industrial causes of methemoglobinemia. Dermal exposure was a more frequent route of toxicity than inhalation with these compounds." (Ellenhorn, M.J. and D.G. Barceloux. Medical Toxicology - Diagnosis and Treatment of Human Poisoning. New York, NY: Elsevier Science Publishing Co., Inc. 1988.) Can cause methemoglobinemia after acute exposure and anemia and liver damage after chronic exposure; [ICSC]

Exposure Assessment
BEI

Methemoglobin in blood = 1.5% of hemoglobin during or end of shift

Vapor Pressure

0.4 mm Hg

Lethal Concentration

LC50 (rat) = 3,200 mg/m3/4h

Explanatory Notes

Flash point = 127 deg C;

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Methemoglobinemia

Methemoglobinemia, Primary

Dermatotoxin

Skin Burns

IARC Carcinogen

Not Classifiable

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Diseases

Occupational diseases associated with exposure to this agent: