Agent Name

2,4-Dinitrotoluene

CAS Number

121-14-2

Formula

C7-H6-N2-O4

Major Category

Nitrogen Compounds

Synonyms

1-Methyl-2,4-dinitrobenzene; 2,4-DNT; 2,4-Dinitro-1-methylbenzene; 2,4-Dinitromethylbenzene; 2,4-Dinitrotoluene; 2,4-Dinitrotoluol; 4-Methyl-1,3-dinitrobenzene; Toluene, 2,4-dinitro-; Benzene, 1-methyl-2,4-dinitro-; [ChemIDplus]UN3454; UN1600 (molten)

Category

Nitros, Aromatic

Description

Yellow solid; [ICSC] Yellow to red solid; Yellow liquid when heated; [CHRIS]

Sources/Uses

Used to make dyes, explosives, munitions, propellants, rubber chemicals, plastics, and other chemicals; [HSDB] The technical grade (approximately 80/20 of the 2,4/2,6 isomers) is used primarily as an intermediate for toluene diamines and diisocyanates; [IARC]

Comments

Can induce methemoglobinemia; Can be absorbed through skin; [ICSC] A mucous membrane irritant; May cause methemoglobinemia; [HSDB] Allergic contact dermatitis reported in a worker manufacturing explosives and exposed to 2,4-dinitrotoluene and nitroglycerin; [Kanerva, p. 1788] Chronic exposure may cause liver injury, anemia, and neuritis; [CHRIS] Equivocal evidence for human reproductive toxicity; [ToxPlanet: DOE] No evidence of teratogenicity in rats or mice at doses maternally toxic; A decrease in sperm positive females was observed in a study of rats when males were dosed at 240 mg/kg/day; [REPROTOX] See "Dinitrotoluene, all isomers."

Reference Link

Occupational allergic contact dermatitis caused by nitroglycerin

Exposure Assessment
Vapor Pressure

0.000147 mm Hg

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Dinitrotoluenes, solid."

Flammability (NFPA)

1: Must be preheated

Adverse Effects
Skin Sensitizer

Yes

Hepatotoxin

Hepatotoxin, Secondary

Reproductive Toxin

Yes

Methemoglobinemia

Methemoglobinemia, Secondary

IARC Carcinogen

Possible Carcinogen

ACGIH Carcinogen

Confirmed Animal

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: