Agent Name

2,4-Xylidine

CAS Number

95-68-1

Formula

C8-H11-N

Major Category

Nitrogen Compounds

Synonyms

1-Amino-2,4-dimethylbenzene; 2,4-Dimethylaniline; 2,4-Dimethylbenzenamine; 2,4-Dimethylphenylamine; 2-Methyl-p-toluidine; 4-Amino-1,3-dimethylbenzene; 4-Amino-1,3-xylene; 4-Amino-3-methyltoluene; 4-Methyl-o-toluidine; Aniline, 2,4-dimethyl-; Benzenamine, 2,4-dimethyl-; m-4-Xylidine; m-Xylidine; meta-Xylidine; [ChemIDplus] UN1711

Category

Amines, Aromatic

Description

Clear, pale yellow liquid; Turns reddish to brown when exposed to air; [ICSC] Dark brown liquid; [CAMEO] Colorless to tan liquid; [HSDB] Yellow liquid; [Alfa Aesar MSDS]

Sources/Uses

Used to make pharmaceuticals, pesticides, dyes, and photographic chemicals; [HSDB] Also used to make wood preservatives, wetting agents for textiles, frothing agents for ore dressing, metal complexes, and special lacquers; [ToxPlanet: EPA PPRTV]

Comments

An eye and mild skin irritant; Can be absorbed through skin; Inhalation of high concentrations can cause methemoglobinemia and lowering of consciousness; Repeated or chronic exposure may have effects on the blood (anemia), liver, and kidney; High dose animal studies have produced liver necrosis, inhibition of DNA synthesis in the testes, and evidence of mutagenicity; [ICSC] A severe eye irritant in rabbits, with corneal opacity and conjunctival irritation persisting in some animals until study termination (21 days); Produced skin sensitization in 50% of guinea pigs using a modified Buehler method; [ToxPlanet: EPA TSCATS] An irritant; Toxic by ingestion, inhalation, and skin absorption; May have cumulative adverse effects to organs; [Alfa Aesar MSDS] See "Xylidine, mixed isomers."

Exposure Assessment
Vapor Pressure

0.13 mm Hg

Lethal Concentration

LC50 (rat) = 1,530 mg/m3/4hr

Explanatory Notes

LC50 (mouse) = 149 ppm/7hr; The Guide in the Emergency Response Guidebook is for "Xylidines."

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Methemoglobinemia

Methemoglobinemia, Secondary

IARC Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Other Information

No other related information on this agent was found.