Agent Name

2,4-Xylidine

CAS Number

95-68-1

Formula

C8-H11-N

Major Category

Nitrogen Compounds

Synonyms

1-Amino-2,4-dimethylbenzene; 2,4-Dimethylaniline; 2,4-Dimethylbenzenamine; 2,4-Dimethylphenylamine; 2-Methyl-p-toluidine; 4-Amino-1,3-dimethylbenzene; 4-Amino-1,3-xylene; 4-Amino-3-methyltoluene; 4-Methyl-o-toluidine; Aniline, 2,4-dimethyl-; Benzenamine, 2,4-dimethyl-; m-4-Xylidine; m-Xylidine; meta-Xylidine; [ChemIDplus] UN1711

Category

Amines, Aromatic

Description

Clear, pale yellow liquid; Turns reddish to brown when exposed to air; [ICSC] Dark brown liquid; [CAMEO] Colorless to tan liquid; [HSDB] Yellow liquid; [Alfa Aesar MSDS]

Sources/Uses

Used to make pharmaceuticals, pesticides, dyes, and photographic chemicals; [HSDB] Also used to make wood preservatives, wetting agents for textiles, frothing agents for ore dressing, metal complexes, and special lacquers; [ToxPlanet: EPA PPRTV]

Comments

An eye and mild skin irritant; Can be absorbed through skin; Inhalation of high concentrations can cause methemoglobinemia and lowering of consciousness; Repeated or chronic exposure may have effects on the blood (anemia), liver, and kidney; High dose animal studies have produced liver necrosis, inhibition of DNA synthesis in the testes, and evidence of mutagenicity; [ICSC] A severe eye irritant in rabbits, with corneal opacity and conjunctival irritation persisting in some animals until study termination (21 days); Produced skin sensitization in 50% of guinea pigs using a modified Buehler method; [ToxPlanet: EPA TSCATS] An irritant; Toxic by ingestion, inhalation, and skin absorption; May have cumulative adverse effects to organs; [Alfa Aesar MSDS] See "Xylidine, mixed isomers."

Exposure Assessment
Vapor Pressure

0.13 mm Hg

Lethal Concentration

LC50 (rat) = 1,530 mg/m3/4hr

Explanatory Notes

LC50 (mouse) = 149 ppm/7hr; The Guide in the Emergency Response Guidebook is for "Xylidines."

Flammability (NFPA)

1: Must be preheated

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Methemoglobinemia

Methemoglobinemia, Secondary

IARC Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Biomedical References

Search PubMed

Related Information in HazMap
Other Information

No other related information on this agent was found.