Agent Name

gamma-Valerolactone

Alternative Name

2(3H)-Furanone, dihydro-5-methyl-

CAS Number

108-29-2

Formula

C5-H8-O2

Major Category

Other Classes

Synonyms

2(3H)-Furanone, dihydro-5-methyl-; 4-Hydroxypentanoic acid lactone; 4-Hydroxyvaleric acid lactone; 4-Methyl-4-hydroxybutanoic acid lactone; 4-Methyl-gamma-butyrolactone; 4-Pentanolide; 4-Valerolactone; 5-Methyltetrahydro-2-furanone; Dihydro-5-methyl-2(3H)-furanone; Pentanoic acid, 4-hydroxy-, gamma-lactone; Pentanolide-1,4; Valeric acid, 4-hydroxy-, gamma-lactone; gamma-Methyl-gamma-butyrolactone; gamma-Pentalactone; gamma-Valerolakton [Czech]; gamma-Valeryllactone; [ChemIDplus]

Category

Lactones

Description

Colorless liquid; [CAMEO]

Sources/Uses

A metabolite of n-hexane; [ChemIDplus] Used as flavoring agent or adjuvant; [FDA] A constituent of crude polyligneous acid; Used in dye bathes (coupling agent), brake fluid, cutting oils, and as a solvent for adhesives, insecticides, and lacquers; [NTP]

Comments

A mild skin irritant; Causes general anesthesia in oral lethal-dose studies of rabbits and rats; [RTECS] A skin, eye, mucous membrane, and upper respiratory tract irritant; [NTP] Safe when used as a flavoring agent in food; [JECFA] An irritant; [Alfa Aesar MSDS] See "Butyrolactones."

Exposure Assessment
Explanatory Notes

VP = 0.5 mm Hg at 29 deg C; [CAMEO]

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Links to Other NLM Databases
Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: