Agent Name

Polymethylene polyphenyl isocyanate

CAS Number


Major Category

Plastics & Rubber


CR 200; Coronate MR 200; Desmodur 44V20; Desmodur PU 1520A20; E 534; Isobind 100; Isocyanate 580; Isocyanic acid, polymethylenepolyphenylene ester; Isonate 390P; Isoset CX 11; Kaiser NCO 20; Lupranate M 10; Lupranate M 20S; Lupranate M 70; Luprinate M 20; MDI-CR; MDI-CR 100; MDI-CR 200; MDI-CR 300; MR 200; MR 2000; Millionate 300; Millionate MR; Millionate MR 100; Millionate MR 200; Millionate MR 300; Millionate MR 340; Millionate MR 400; Millionate MR 500; Mirionate MR; Mobay MRS; Mondur E 429; Mondur E 441; Mondur E 541; Mondur MR; Mondur MR 200; Mondur MRS; Mondur MRS 10; NCO 20; Niax AFPI; PAPI; PAPI 135; PAPI 20; PAPI 27; PAPI 580; PAPI 901; Poly(methylene phenylene isocyanate); Poly(phenylenemethylene isocyanate); Polymeric diphenyl methylene diisocyanate; Polymeric diphenylmethane diisocyanate; Polymeric mdi; Polymethyl polyphenyl polyisocyanate; Polymethylene poly(phenyl isocyanate); Polymethylene polyphenyl polyisocyanate; Polymethylene polyphenyleneisocyanate; Polymethylenepolyphenylene isocyanate polymer; Polymethylenepolyphenylene polyisocyanate; Polyphenylene polymethylene polyisocyanate; Polyphenylpolymethylene polyisocyanate; Rubinate M; Rubinate MF 178; Rubinate MF 182; Sumidur 44V10; Sumidur 44V20; Sumidur 44VM; Suprasec 1042; Suprasec DC; Systanat MR; Systanate MR; Takenate 300C; Tedimon 31; Thanate P 210; Thanate P 220; Thanate P 270; Polymethylenepolyphenyl isocyanate; Polymeric diphenylmethanediisocyanate; Polymethylenepolyphenylene isocyanate; [ChemIDplus] PMDI; [Reference #2]




Dark amber viscous liquid; [HSDB]


This resin is used as a binder in particle board and foundry cores. It is used to make polyurethane elastomers for shoes and automobile bumpers. [HSDB] The polymeric mixture (PMDI) is the main commercial form of diphenylmethane diisocyanate (MDI); Composition varies by manufacturer; Used (in aerosol form) to make rigid and flexible foam, foundry resin sand binders, and heat insulating material; [Reference #2]


Occupational asthma reported in paint shop worker; [Malo] A skin and eye irritant; Inhalation may cause wheezing, cough, and reduction of pulmonary function; [CHRIS] Danger of skin and airway sensitization; [MAK] See "Methylene bisphenyl isocyanate." See "DIISOCYANATES."

Reference Link

Prevalence of occupational asthma in spray painters exposed to several types of isocyanates, including polymethylene polyphenylisocyanate

Exposure Assessment

0.05 mg/m3, inhalable fraction

Vapor Pressure

3.0E-6 mm Hg

Lethal Concentration

LC50 (rat) = 490 mg/m3/4h

Reference Link

INCHEM CICADs: Diphenylmethane diisocyanate (MDI) - 2000

Adverse Effects
Skin Sensitizer




IARC Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information


Chemical Information

Search ChemIDplus

Biomedical References

Search PubMed

Related Information in HazMap

Occupational diseases associated with exposure to this agent:


Industrial Processes with risk of exposure: