Agent Name

Pinacolyl alcohol

Alternative Name

3,3-Dimethyl-2-butanol

CAS Number

464-07-3

Formula

C6-H14-O

Major Category

Solvents

Synonyms

2,2-Dimethyl-3-butanol; tert-Butyl methyl carbinol; 2-Butanol, 3,3-dimethyl-; 3,3-Dimethylbutan-2-ol; 3,3-Dimethyl-2-butanol; [ChemIDplus] Pinacoline alcohol; [Sigma-Aldrich MSDS] UN1987

Category

Alcohols (<C12)

Description

Colorless liquid; mp = 5.6 deg C; [HSDB] Clear light yellow liquid; [Sigma-Aldrich MSDS]

Sources/Uses

Used to make chemical warfare agents (i.e. Soman); [HSDB]

Comments

Causes CNS depression and nephrotoxicity in experimental animals; Clinical effects likely to be similar to ethanol, based on closely related structure; Ataxia, mild hypoxemia, hypercapnia, lachrymation, depressed respiration and motor activity, increased cholesterol and bilirubin, and acute tubular necrosis and renal failure observed in inhalation studies of rats; [Reference #1] May cause irritation; [Sigma-Aldrich MSDS]

Reference Link

INCHEM: Pinacolyl alcohol (PIM 981 - 2001)

Exposure Assessment
Vapor Pressure

8.81 mm Hg

Lethal Concentration

LCLo (rat) = 3,600 ppm

Explanatory Notes

LC50 (rat) = 15,000 mg/m3; [RTECS] The Guide in the Emergency Response Guidebook is for "Alcohols, n.o.s."

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: