Agent Name

D-Camphor

CAS Number

464-49-3

Formula

C10-H16-O

Major Category

Biological Agents

Synonyms

(+)-2-Bornanone; (1R)-(+)-Camphor; (1R)-Camphor; (1R,4R)-1,7,7-Trimethylbicyclo(2.2.1)heptan-2-one; (R)-(+)-Camphor; (R)-Camphor; Alcanfor; Bicyclo(2.2.1)heptan-2-one, 1,7,7-trimethyl-, (1R)-; Camphor USP; Camphor, (+)-; Camphor, (1R,4R)-(+)-; D-(+)-Camphor; Formosa camphor; Japanese camphor; Laurel camphor; d-2-Bornanone; d-2-Camphanone; d-Camphor; (+)-Bornan-2-one; Bicyclo(2.2.1)heptan-2-one, 1,7,7-trimethyl-, (1R,4R)-; Bicyclo(2.2.1)heptan-2-one, 1,7,7-trimethyl-, (1theta)-; (+)-Camphor; Camphor, D-; [ChemIDplus] UN2717

Category

Plant Oils and Extracts

Description

Colorless, transparent solid; [Merck Index] Colorless or white solid with a penetrating odor; [CAMEO] White crystalline solid; [Alfa Aesar MSDS]

Sources/Uses

Naturally occurring form of camphor; Used in organic synthesis and as an odorant, flavoring agent, moth repellent, preservative, and plasticizer in cosmetics; Also used as a topical analgesic and antipruritic; [Merck Index] Used primarily in medicaments; Used industrially as a plasticizer for cellulose esters and ethers, to make plastics, and as a solvent in cosmetics; [NTP - Final Report on Developmental Toxicity] Used as a coloring agent, flavor enhancer, and flavoring agent or adjuvant; [FDA] A major constituent of pine oil; Used as a plasticizer for cellulose nitrate, explosives, and lacquers, to make incense, in varnishes, odorants, embalming fluids, pyrotechnics, insecticides, insect repellents, and for moth and mildew proofing; [NTP]

Comments

Considered highly toxic by ingestion, with an estimated human lethal dose of 3.5-35 grams (50-500 mg/kg); Autopsies of human poisonings have shown damage to the liver, kidney, and brain; [NTP - Final Report on Developmental Toxicity] Camphor used topically during pregnancy in not likely to cause teratogenic effects; [ToxPlanet: TERIS] Safe when used as a flavoring agent in food; [JECFA] A severe skin, eye, mucous membrane, and upper respiratory tract irritation; High concentrations may cause corrosive injuries; May cause CNS depression and other nervous system effects; Harmful by ingestion, inhalation, and skin absorption; [NTP] Included in list of "established contact allergens in humans"; [ToxPlanet: EC: Scientific Committee on Consumer Safety: Fragrance allergens in cosmetic products (2011)] A skin and strong eye irritant; [Alfa Aesar MSDS] See "Camphor, synthetic."

Exposure Assessment
Explanatory Notes

VP = 1 mm Hg at 41.5 deg C; [NTP] The Guide in the Emergency Response Guidebook is for "Camphor."

Flammability (NFPA)

2: High ambient temperature required

Adverse Effects
Skin Sensitizer

Yes

Neurotoxin

Other CNS Neurotoxin

Hepatotoxin

Hepatotoxin, Secondary

Links to Other NLM Databases
Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: