Agent Name

4-Methylimidazole

CAS Number

822-36-6

Formula

C4-H6-N2

Major Category

Nitrogen Compounds

Synonyms

4(or 5)-Methylimidazole; 4-Me-i; 1H-Imidazole, 4-methyl-; 1H-Imidazole, 5-methyl-; 4-Methyl-1H-imidazole; Imidazole, 4-methyl-; [ChemIDplus] 4MI; [HSDB]

Category

Imidazoles

Description

Solid; [HSDB] Light yellow solid; [NTP] Light yellow powder; [Sigma-Aldrich MSDS]

Sources/Uses

Used to make pharmaceuticals, antiseptic agents, and photo developing solutions; [HSDB] Present in caramel coloring, tobacco smoke, wine, soy sauce, and other foods; Also formed when ammonia is added to livestock feed to increase nutritional value; Used to make pharmaceuticals, photographic and photothermographic chemicals, dyes, pigments, agricultural chemicals, rubber, and inks; Also used in oven cleaners, as a crosslinking agent for epoxy resin hardeners, corrosion inhibitor for cooling water, and in absorbents that remove acid gases from hydrocarbon or synthesis gas; [NTP]

Comments

No histopathological changes observed in 15-day oral studies of rats and mice; 14-week oral studies produced tremors, ataxia, anemia, hepatocytic vacuolization, and testicular degeneration in rats and anemia, liver cytoplasmic vacuolization, and renal degeneration in mice; Histopathological liver changes also observed in 106-week oral study of rats; [HSDB] Causes neurological effects including hyperexcitability, convulsions, and seizures in livestock and experimental animals; Reproductive organ toxicity and decreased fertility observed in male rats; Evidence of carcinogenicity: none in male rats; equivocal in female rats; clear evidence in male and female mice; [NTP] Irritating or corrosive to skin and irritating to eyes in rabbits; [IUCLID] Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; Harmful by ingestion; [Sigma-Aldrich MSDS] See "2-Methylimidazole."

Reference Link

IARC 2012: 4-Methylimidazole

Exposure Assessment
Vapor Pressure

0.01 mm Hg

Adverse Effects
Toxic Pneumonitis

Yes

Neurotoxin

Other CNS Neurotoxin

Hepatotoxin

Hepatotoxin, Secondary

Dermatotoxin

Skin Burns

IARC Carcinogen

Possible Carcinogen

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Processes

Industrial Processes with risk of exposure: