Agent Name

5-Diazouracil

CAS Number

2435-76-9

Formula

C4-H2-N4-O2

Major Category

Other Uses

Synonyms

2,4-Diossi-5-diazopirimidina [Italian]; 2,6-Dioxo-5-diazopyrimidine; 5-Diazo-2,4(1H,3H)-pyrimidinedione; 5-Diazopyrimidine-2,4(3H)-dione; Diazouracil; 2,4(1H,3H)-Pyrimidinedione, 5-diazo- (9CI); 2,4(3H,5H)-Pyrimidinedione, 5-diazo-; [ChemIDplus] DU; 2,4-Dioxo-5-diazopyrimidine; 5-Diazo-2,4-dioxopyrimidine; [Merck Index] 5-DU; [RTECS]

Category

Biochemical Research

Description

Solid; Sensitive to light, air, and temperature; [Merck Index]

Sources/Uses

Used in cancer research; [Merck Index]

Comments

Intraperitoneal LD50 (mouse) = 30.8 mg/kg; [RTECS] A study from 1973 reported that 5-20 mg/kg administered on day 10 produced embryo lethality but no teratogenicity in mice; [ToxPlanet: Shepard's Catalog of Teratogenic Agents] May cause irritation; [Sigma-Aldrich MSDS]

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