Agent Name

6-Methylhept-5-en-2-one

CAS Number

110-93-0

Formula

C8-H14-O

Major Category

Other Classes

Synonyms

Methylheptenone; 2-Methyl-2-hepten-6-one; 2-Methyl-6-oxo-2-heptene; 2-Oxo-6-methylhept-5-ene; 6-Methyl-5-hepten-2-one; 6-Methyl-5-hepten-2-one (natural); Sulcatone; 5-Hepten-2-one, 6-methyl-; Methyl heptenone; [ChemIDplus] 2-Methylhepten-2-on-6; 6-Methyl-delta5-hepten-2-one; [IUCLID] UN1224

Category

Aliphatic Ketones, Other

Description

Colorless to yellowish liquid with a strong odor; [OECD SIDS]

Sources/Uses

Used as flavor enhancer; [FDA] Used mainly for chemical synthesis (closed systems); Also used in cleaning agents and as a flavor or aroma additive in cosmetics and food; [OECD SIDS]

Comments

No skin sensitization observed in study of 25 volunteers; [IUCLID] Mild skin irritation observed in rabbits (nearly reversed in 48 hours); Causes mild corneal opacity and mild conjunctival redness in rabbits 24 hours following application (completely reversed within 8 days); Not a skin sensitizer in guinea pigs; Significant effects to sperm, significantly increased absolute and relative liver and kidney weights, decreased size of the testes and epididymis, and histopathological changes of the liver, kidney, and testes observed in 90-day oral study of rats at the highest tested dose (1,000 mg/kg/day, with a LOAEL of 50 mg/kg/day); [OECD SIDS] Safe when used as a flavoring agent in food; [JECFA] May cause irritation; [Sigma-Aldrich MSDS]

Exposure Assessment
Vapor Pressure

0.75 mm Hg

Lethal Concentration

LC50 (rat) > 13,960 mg/m3/4hr

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Ketones, liquid, n.o.s."

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Links to Other NLM Databases
Toxicity Information

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Chemical Information

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Related Information in HazMap
Other Information

No other related information on this agent was found.