Agent Name

Pulegone

CAS Number

89-82-7; 15932-80-6

Formula

C10-H16-O

Major Category

Biological Agents

Synonyms

(+)-(R)-Pulegone; (+)-Pulegone; (1R)-(+)-p-Menth-4(8)-en-3-one; (R)-(+)-Pulegone; (R)-Pulegone; 1-Isopropylidene-4-methyl-2-cyclohexanone; 1-Methyl-4-isopropylidene-3-cyclohexanone; 3-Methyl-6-isopropylidenecyclohexanone; 4(8)-p-Menthen-3-one, delta-; 5-Methyl-2-(1-methylethylidene)cyclohexanone, (R)-; Pulegon; R-Pulegone; Pulegone (natural); Pulegone, d-; d-Pulegone; p-Menth-4(8)-en-3-one, (R)-(+)-; Cyclohexanone, 5-methyl-2-(1-methylethylidene)-, (5R)-; Cyclohexanone, 5-methyl-2-(1-methylethylidene)-, (R)-; Cyclohexanone, 5-methyl-2-(1-methylethylidene)-, (theta)-; Pulegone; p-Menth-4(8)-en-3-one; [ChemIDplus] (5R)-5-Methyl-2-(1-methylethylidene)cyclohexanone; R-(+)-p-Menth-4(8)-en-3-one; [Merck Index]

Category

Plant Oils and Extracts

Description

Liquid with a pleasant odor between peppermint and camphor; [Merck Index] Clear light brown liquid; [Sigma-Aldrich MSDS]

Sources/Uses

A natural oil in plants of the Labiatae family; [Merck Index] Used as flavoring agent or adjuvant; [FDA] Also used in dental products, as fragrance agents, and in herbal medicines; [NTP]

Comments

All early deaths in 2-week oral studies of rats and mice at doses >300 mg/kg attributed to liver toxicity; Non-neoplastic lesions of the liver, kidney, nose, and forestomach of rats and mice observed in 2-year oral studies; Evidence for carcinogenic activity: None in male rats; some in female rats; clear evidence (liver neoplasms) in male and female mice; [NTP] Safe when used as a flavoring agent in food; [JECFA] May cause irritation; May be harmful if swallowed or inhaled; [Sigma-Aldrich MSDS]

Exposure Assessment
Vapor Pressure

138 mm Hg

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Links to Other NLM Databases
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Chemical Information

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