Agent Name

1,1,1,2-Tetrachloroethane

CAS Number

630-20-6

Formula

C2-H2-Cl4

Major Category

Solvents

Synonyms

Ethane, 1,1,1,2-tetrachloro-; 1,1,1,2-Tetrachlorethane; [ChemIDplus] (Chloromethyl) trichloromethane; Asym-tetrachloroethane; F130A; HCC 130A; TCA; [CAMEO] UN1702

Category

Chlorinated Aliphatics

Description

Yellowish-red liquid; [NIOSH] Yellow to red liquid; [ICSC] Clear colorless liquid; [NTP]

Sources/Uses

Used to make other organic chemicals; [ATSDR ToxFAQs] Used as a solvent; [HSDB]

Comments

Target organs are skin, eyes, CNS, and liver. [NIOSH] A skin and eye irritant; May cause CNS effects; [ICSC] An irritant and lachrymator; May cause CNS depression, albuminuria, hematuria, hepatomegaly, jaundice, nephritis, polyneuritis, and skin and eye burns; No evidence of carcinogenicity in mice, equivocal evidence in male rats, and no evidence in female rats; [NTP] An irritant that may cause serious eye injury; Harmful by ingestion and inhalation; Targets the nerves, liver, aned kidney; [Sigma-Aldrich MSDS] See "1,1,2,2-Tetrachloroethane."

Restricted

Commercial production has ceased in the U.S. It is still used as a chemical intermediate to synthesize organic chemicals. [ATSDR ToxFAQs]

Exposure Assessment
Vapor Pressure

14 mm Hg

Lethal Concentration

LC50 (rat) = 2,100 ppm/4hr

Adverse Effects
Lacrimator

Yes

Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Secondary

IARC Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

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Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

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Processes

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