Agent Name

Titanium tetrachloride

CAS Number

7550-45-0

Formula

Cl4-Ti

Major Category

Toxic Gases & Vapors

Synonyms

Tetrachlorotitanium; Tetrachlorure de titane [French]; Titaantetrachloride [Dutch]; Titane (tetrachlorure de) [French]; Titanic chloride; Titanio (tetracloruro di) [Italian]; Titanium chloride; Titanium chloride (TiCl4); Titanium chloride (TiCl4), (T-4)-; Titanium tetrachloride; Titantetrachlorid [German]; [ChemIDplus] UN1838

Category

Other Toxic Gases & Vapors

Description

A colorless fuming liquid with a pungent odor; [CAMEO]

Sources/Uses

Used to manufacture titanium-containing compounds; used as white pigments in paints; [ATSDR ToxFAQs] Used in chemical vapor deposition to apply coatings to metals and other materials with high melting points--the process involves bubbling hydrogen and nitrogen though a bath of titanium tetrachloride or vanadium tetrachloride. [Scand J Work Environ Health 1991;17:369-79] Used in dyeing textiles and leather (mordant), making glass, and in smoke screens; [AIHA]

Comments

Can cause pneumonitis; [Table 16.3, Sullivan, p. 213] Liquid causes second degree burns after contact for a few minutes. [CHRIS] Corrosive to skin; [Quick CPC] When TiCl4 comes in contact with water, HCl is rapidly generated. [ATSDR ToxFAQs] See [Park T, et al. Diffuse Endobronchial Polyposis Following A Titanium Tetrachloride Inhalation Injury. Am Rev Respir Dis. 1984 Aug;130(2):315-7] A corrosive substance that can cause injury to the skin, eyes, and respiratory tract; Inhalation may cause pulmonary edema; [ICSC]

Exposure Assessment
TIH

Yes

Dangerous When Wet

Yes - A material that, by contact with water, is liable to become spontaneously flammable or to give off flammable or toxic gas at a rate greater than 1 L per kilogram of the material, per hour; [ERG 2004]

WEEL

0.5 mg/m3

Vapor Pressure

9.88 mm Hg

Lethal Concentration

LC50 (rat) = 400 mg/m3

Reference Link

ATSDR - ToxFAQs - Titanium Tetrachloride

Adverse Effects
Toxic Pneumonitis

Yes

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Health Studies

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Toxicity Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: