Agent Name

Leptophos

CAS Number

21609-90-5

Formula

C13-H10-Br-Cl2-O2-P-S

Major Category

Pesticides

Synonyms

(+-)-Leptophos; Abar; Abar (velsicol); Fosvel; K62-105; MBCP; NK 711; O-(2,5-Dichloro-4-bromophenyl) O-methyl phenylthiophosphonate; O-(4-Bromo-2,5-dichlorophenyl) O-methyl phenylphosphonothioate; O-Methyl O-2,5-dichloro-4-bromophenyl phenylthiophosphonate; O-Methyl-O-(4-bromo-2,5-dichlorophenyl)phenyl thiophosphonate; OMS 1438; Oleophosvel; Phenylphosphonothioic acid O-(4-bromo-2,5-dichlorophenyl) O-methyl ester; Phosphonothioic acid, phenyl-, O-(4-bromo-2,5-dichlorophenyl) O-methyl ester (8CI)(9CI); Phosvel; VCS 5-D; VCS-506; Velsicol 506; Velsicol VCS 506; [ChemIDplus]

Category

Organophosphate Insecticides

Description

Tan solid; [Merck Index] Colorless or white solid; Technical material is light-brown solid; [CAMEO]

Sources/Uses

Used as an insecticide; [Merck Index] For export use only; Used as an insecticide for rice, cotton, fruit, and vegetables; [EPA OHM/TADS]

Comments

A small number of the organophosphates (OPs) can Induce Delayed Neuropathy (OPIDN). OPIDN usually occurs after ingestion and is usually nonoccupational. [Levy, p. 431] A highly toxic cholinesterase inhibitor that may cause permanent injury or death as a result of normal use; [CAMEO] A weak cholinesterase inhibitor, but is metabolized to the oxygen analog that is relatively potent; Not teratogenic in rabbits dosed orally during pregnancy; May cause delayed neurotoxicity in occupational exposures (delayed neurotoxicity observed in hens); [EPA OHM/TADS] May cause irritation and organ damage; Highly toxic by ingestion; Toxic by skin absorption; [Aldrich MSDS]

Restricted

Banned in the USA in 1975 due to delayed neurotoxic effects; [HSDB]

Exposure Assessment
BEI

Cholinesterase activity in red cells = 70% of individual's baseline, sample time discretionary; [ACGIH]

Vapor Pressure

2.3E-8 mm Hg

Adverse Effects
Neurotoxin

Motor Neuropathy

Other Poison

Organophosphate

Links to Other NLM Databases
Health Studies

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Chemical Information

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Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: