Agent Name

Mipafox

CAS Number

371-86-8

Formula

C6-H16-F-N2-O-P

Major Category

Pesticides

Synonyms

Bis(isopropylamido) fluorophosphate; Bis(isopropylamido)fluorophosphate; Bis(monoisopropylamino)fluorophosphate; Bis(monoisopropylamino)fluorophosphine oxide; Bisisopropylaminofluorophosphine oxide; Di(isopropylamido)phosphoryl fluoride; Fluorobisisopropylaminophosphine oxide; Fluorure de N,N'-diisopropyle phosphorodiamide [French]; Isopestox; Mipafox [ISO]; N,N'-Diisopropil-fosforodiammido-fluoruro [Italian]; N,N'-Diisopropyl-diamido-fosforzuur-fluoride [Dutch]; N,N'-Diisopropyl-diamido-phosphorsaeure-fluorid [German]; N,N'-Diisopropyldiamidophosphoryl fluoride; N,N'-Diisopropylphosphorodiamidic fluoride; Peston XV; Pestox 15; Pestox XV; Phosphine oxide, fluorobis(isopropylamino)-; Phosphorodi(isopropylamidic) fluoride; Phosphorodiamidic fluoride, N,N'-bis(1-methylethyl)-; Phosphorodiamidic fluoride, N,N'-diisopropyl-; [ChemIDplus]

Category

Organophosphate Insecticides

Description

Odorless crystals; [HSDB]

Sources/Uses

Used as an insecticide; [Merck Index] Used in neurotoxicology studies; [HSDB]

Comments

A small number of the organophosphates (OPs) can Induce Delayed Neuropathy (OPIDN). OPIDN usually occurs after ingestion and is usually nonoccupational. [Levy, p. 431] Immediate and delayed neurotoxic effects observed in experimental animals; [HSDB] The average of two baseline respective cholinesterase activity determinations three days apart, with no exposures to enzyme inhibiting pesticides for at least 30 days, is recommended for each worker prior to exposure to cholinesterase inhibitors because of large inter-individual differences in published baseline values. To be established at least once a year. Removal from workplace exposures is recommended until the cholinesterase activity returns to within 20% of baseline. [TLVs and BEIs]

Restricted

Not used in the US; [HSDB] "This chemical ingredient is not found in any products." [NPIRS]

Exposure Assessment
BEI

Acetylcholinesterase activity in red blood cells = 70% of individual's baseline; Butylcholinesterase activity in serum or plasma = 60% of individual's baseline; Sample at end of shift; [TLVs and BEIs]

Vapor Pressure

0.001 mm Hg

Adverse Effects
Neurotoxin

Motor Neuropathy

Other Poison

Organophosphate

Links to Other NLM Databases
Health Studies

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Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: