Agent Name

3,3'-Dimethylbenzidine dihydrochloride

Alternative Name

o-Tolidine dihydrochloride

CAS Number

612-82-8

Formula

C14-H16-N2.2Cl-H

Major Category

Nitrogen Compounds

Synonyms

o-Tolidine dihydrochloride; 4,4'-Diamino-3,3'-dimethylbiphenyl dihydrochloride; (1,1'-Biphenyl)-4,4'-diamine, 3,3'-dimethyl-, dihydrochloride; (1,1'-Biphenyl)-4,4'-diamine, 3,3'-dimethyl-, hydrochloride (1:2); 4,4'-Bi-o-toluidine dihydrochloride; Benzidine, 3,3'-dimethyl-, dihydrochloride; [ChemIDplus] DMB-2HCl; DMB dihydrochloride; [NTP]

Category

Amines, Polyaromatic

Description

Light tan solid; [CAMEO] Light red powder; Hygroscopic; [Sigma-Aldrich MSDS]

Sources/Uses

o-Tolidine: Used to make dyes; Also used as a reagent to detect gold and free chlorine in water; [Merck Index]

Comments

Causes other endocrine changes and weight loss in 14-day oral studies of rats; Causes changes in thymus weight, bone marrow, and erythrocyte counts in 13-week oral studies of rats; [RTECS] May cause irritation; Targets the liver, kidney, and GI tract; Harmful by ingestion; [Sigma-Aldrich MSDS] See "o-Tolidine."

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

NTP Carcinogen

Anticipated Human Carcinogen

Links to Other NLM Databases
Toxicity Information

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Chemical Information

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Other Information

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