Agent Name

alpha-Ketoglutaric acid

CAS Number

328-50-7

Formula

C5-H6-O5

Major Category

Other Uses

Synonyms

2-Oxo-1,5-pentanedioic acid; 2-Oxopentanedioic acid; Alphaketoglutaric acid; Glutaric acid, alpha keto; alpha Ketoglutarate; alpha-Ketoglutaricum acidum; alpha-Oxoglutaric acid; alpha-Ketoglutarate; 2-Oxoglutaric acid; Glutaric acid, 2-oxo- (8CI); Pentanedioic acid, 2-oxo-; [ChemIDplus]

Category

Biochemical Research

Description

Solid; [Merck Index] White to off-white solid; [Acros Organics MSDS]

Sources/Uses

"Plays an important role in amino acid metabolism (transamination)"; [Merck Index] Involved in the Krebs cycle of intermediary metabolism; Has been used as a nutritional supplement; [ExPub: TERIS] Used as flavoring agent or adjuvant; [FDA]

Comments

Causes convulsions in acute intraperitoneal studies of mice; Causes other liver changes and multiple enzyme effects in 20-week intermittent oral studies of rats; [RTECS] Safe when used as a flavoring agent in food; [JECFA] An eye irritant that may cause corneal injury; [Acros Organics MSDS]

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