Agent Name

Diethylene glycol monobutyl ether

Alternative Name

DEGBE

CAS Number

112-34-5

Formula

C8-H18-O3

Major Category

Solvents

Synonyms

2-(2-Butoxyethoxy)ethanol; BUCB; Butoxy diethylene glycol; Butoxydiethylene glycol; Butoxydiglycol; Butoxyethoxyethanol; Butyl Ethyl Cellosolve; Butyl carbitol; Butyl diglycol; Butyl digol; Butyl dioxitol; Diethylene glycol butyl ether; Diethylene glycol monobutyl ether; Diethylene glycol n-butyl ether; Diethylene gylcol monobutyl ether; Diglycol monobutyl ether; Dowanol DB; Ektasolve DB; Ethanol, 2,2'-oxybis-, monobutyl ether; Ethanol, 2-(2-butoxyethoxy)-; Glycol ether DB; Jeffersol DB; O-Butyl diethylene glycol; Poly-Solv DB; [ChemIDplus]

Category

Glycol Ethers (E Series)

Description

Colorless liquid with a mild pleasant odor; [CAMEO]

Sources/Uses

Used as a solvent and diluent for polymers, resins, coatings, inks, cleaners, and metalworking fluids; [HSDB] Used as a solvent (nitrocellulose, oils, dyes, gums, soaps, and polymers) and coalexcing agent in latex paints; In paints containing 1.5% w/w, painters exposed to 4-5 mg/m3; [ACGIH]

Comments

"TLV Basis" is hematologic, liver, and kidney effects; The NOAEL for rats was 250 mg/kg/day, equivalent to a worker exposed to 260 ppm; [ACGIH] In animal studies, no genotoxic or mutagenic effects and no acute adverse effects after exposure to 18 ppm; No evidence of liver, kidney, blood, or reproductive toxicity in humans; [Sullivan, p. 1204] A mild skin irritant and severe eye irritant that is absorbed through the skin; [CHS, p. 164] The toxicity of diethylene glycol ethers is lower than that of the ethylene glycol ethers. Animal studies: Can cause central nervous system depression, liver, and kidney injury; [HSDB] A skin and eye irritant; [ICSC] Rats in high-dose feeding studies for 6 weeks have decreased red blood cell counts; [ToxPlanet: CPS&Q: IUCLID Reports] "It is considered an exceptional allergen." [Kanerva, p. 1763]

Reference Link

Occupational contact dermatitis from diethylene glycol monobutyl ether in a podiatrist.

Exposure Assessment
Skin Designation (ACGIH)

No

TLV (ACGIH)

10 ppm

MAK

10 ppm, sum of the concentrations of DGBE and its acetate in air

Vapor Pressure

0.02 mm Hg

Explanatory Notes

Flash point = 78 deg C;

Flammability (NFPA)

2: High ambient temperature required

Adverse Effects
Skin Sensitizer

Yes

Anemia

Anemia, Hemolytic

Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Secondary

Nephrotoxin

Yes

Reproductive Toxin

Yes

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Biomedical References

Search PubMed

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: