Agent Name

Barbituric acid

CAS Number

67-52-7

Formula

C4-H4-N2-O3

Major Category

Nitrogen Compounds

Synonyms

2,4,6(1H,3H,5H)-Pyrimidinetrione; 2,4,6-Pyrimidinetriol; 2,4,6-Pyrimidinetrione; 2,4,6-Trihydroxypyrimidine; 2,4,6-Trioxohexahydropyrimidine; 6-Hydroxyuracil; Hydrouracil, 6-hydroxy-; Malonylurea; Pyrimidinetriol; Pyrimidinetrione; Urea, N,N'-(1,3-dioxo-1,3-propanediyl)-; [ChemIDplus]

Category

Pyrimidines

Description

White powder; [Alfa Aesar MSDS]

Sources/Uses

Used to make plastics and pharmaceuticals; [Merck Index] Discovered in 1864, barbituric acid was the first barbiturate drug--used as a sedative and anticonvulsant; [Wikipedia]

Comments

"Unsubstituted barbituric acid has no hypnotic properties." [Merck Index] Causes somnolence, impaired liver function tests, depressed renal function tests, and other changes in urine composition in acute inhalation studies of rats; Causes somnolence and ataxia in oral lethal-dose studies of mice and rats; Causes somnolence and impaired liver function tests in 30-day intermittent inhalation studies of rats; [RTECS] An irritant; [Alfa Aesar MSDS]

Exposure Assessment
Vapor Pressure

2.17E-9 mm Hg

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Links to Other NLM Databases
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Chemical Information

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Other Information

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