Agent Name

Croton oil

CAS Number

8001-28-3

Formula

Unspecified

Major Category

Biological Agents

Synonyms

Croton resin; Croton tiglium L. oil; Crotonoel [German]; Oils, croton; Oleum tiglii; Olin di croton [Italian]; [ChemIDplus] Tiglium oil; [NTP]

Category

Plant Oils and Extracts

Description

Pale yellow or brownish-yellow liquid with a mild disagreeable odor; Colorless liquid with an unpleasant odor; [CAMEO] Amber viscous liquid; [NTP] Clear dark yellow liquid; [Sigma-Aldrich MSDS]

Sources/Uses

Has been used in cancer research as a co-carcinogen; Has also been used therapeutically as a counter-irritant and cathartic; [Merck Index]

Comments

A mild to severe skin irritant; Causes irritation and inflammatory effects in acute dermal studies of mice; [RTECS] "Viscous, nauseating oil obtained from the shrub Croton tiglium (Euphorbaceae). It is a vesicant and skin irritant used as pharmacologic standard for skin inflammation and allergy and causes skin cancer. It was formerly used as an emetic and cathartic with frequent mortality." [ChemIDplus] A severe skin irritant that may cause vesiculation, necrosis, sloughing, and blisters; [CAMEO] LD50 < 50 mg/kg; A severe skin and eye irritant; [CHRIS] May cause allergic reactions on ingestion; [NTP] A mild skin irritant; [Sigma-Aldrich MSDS]

Adverse Effects
Dermatotoxin

Skin Burns

Links to Other NLM Databases
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Chemical Information

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Other Information

No other related information on this agent was found.