Agent Name

1,2-Benzisothiazolin-3-one

Alternative Name

BIT

CAS Number

2634-33-5

Formula

C7-H5-N-O-S

Major Category

Other Uses

Synonyms

BIT; 1,2-Benzisothiazol-3(2H)-one; 1,2-Benzisothiazolin-3-one; IPX; Proxan; Proxel PL; [ChemIDplus]

Category

Biocides/Disinfectants

Sources/Uses

Used as a preservative in manufacturing, metalworking fluids, pottery molding, plumbing, printing, and laboratory analysis; Used as a preservative in vinyl gloves; [Kanerva, p. 1755]

Comments

Allergic contact dermatitis reported in workers using this preservative, mainly in manufacturing industries (paint, paper, rubber, and air fresheners); [Kanerva, p. 1755] Occupational asthma reported in a chemical worker; [Malo] See "ISOTHIAZOLINONES."

Reference Link

1,2-Benzisothiazolin-3-one (Proxel): irritant or allergen? A clinical study and literature review

Exposure Assessment
Explanatory Notes

"Danger of sensitization of skin." [MAK]

Reference Link

Occupational asthma and rhinitis caused by 1,2-benzisothiazolin-3-one in a chemical worker

Adverse Effects
Skin Sensitizer

Yes

Asthma

Yes

Links to Other NLM Databases
Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: