| Agent Name | Methylisothiazolinone |
|---|---|
| CAS Number | 2682-20-4 |
| Formula | C4-H5-N-O-S |
| Major Category | Other Uses |
| Synonyms | 2-Methyl-3(2H)-isothiazolone; 2-Methyl-4-isothiazolin-3-one; 2-Methyl-2H-isothiazol-3-one; 2-Methyl-4-isothiazolin-3-one calcium chloride; 3(2H)-Isothiazolone, 2-methyl-; MI; [ChemIDplus] 2-Methyl-2,3-dihydroisothiazol-3-one; [ACGIH Guide to Occupational Exposure Values, 2002] MIT; Neolone 950; [Merck Index] 2-Methylisothiazol-3(2H)-one; [ToxPlanet: EC: SCCS - Opinion] UN3261 |
| Category | Biocides/Disinfectants |
| Description | Colorless solid; [Merck Index] Dark yellow powder with lumps; [Sigma-Aldrich MSDS] |
| Sources/Uses | Used as a biocide and preservative in cosmetics, paints, and glues; it is present in Kathon KG, MCI/MI, and Euxyl K100; [Kanerva, p. 1815] Used as an antimicrobial in cosmetics, hygiene products, paints, emulsions, cutting oils, paper coatings, and water storage and cooling units; [Merck Index] Used as a biocide in textile production; [ToxPlanet: Danish Ministry of the Environment] Used as a preservative in pesticide products; [ToxPlanet: EPA - Inert Reassessments] Used as a biocide in pulp/paper mills, industrial process and cooling water systems, oil field operations, and air cleaner systems, and as a preservative in adhesives, coatings, fuels, metalworking fluids, resin emulsions, paints, and wood products; [Reference #1] |
| Comments | Allergic contact dermatitis reported in workers using products containing this preservative; [Kanerva, p. 1815] Danger of skin sensitization; [MAK] Cosmetic preservative that is a recognized contact allergen in consumers; [ToxPlanet: EC: SCCS - Opinion] Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; May cause skin sensitization; Harmful by ingestion; Toxic by inhalation; [Sigma-Aldrich MSDS] See "ISOTHIAZOLINONES." |
| Reference Link | |
| Exposure Assessment | |
| MAK | 0.2 mg/m3, inhalable fraction |
| Explanatory Notes | The Guide in the Emergency Response Guidebook is for "Corrosive solid, acidic, organic, n.o.s." MAK value is for 3:1 mixture of 26172-55-4 and 2682-20-4; |
| Adverse Effects | |
| Skin Sensitizer | Yes |
| Toxic Pneumonitis | Yes |
| Dermatotoxin | Skin Burns |
| Links to Other NLM Databases | |
| Toxicity Information | |
| Chemical Information | |
| Biomedical References | |
| Related Information in HazMap | |
| Diseases | Occupational diseases associated with exposure to this agent: |
| Processes | Industrial Processes with risk of exposure: |
Agent Name
Methylisothiazolinone
CAS Number
2682-20-4
Formula
C4-H5-N-O-S
Major Category
Other Uses
Synonyms
2-Methyl-3(2H)-isothiazolone; 2-Methyl-4-isothiazolin-3-one; 2-Methyl-2H-isothiazol-3-one; 2-Methyl-4-isothiazolin-3-one calcium chloride; 3(2H)-Isothiazolone, 2-methyl-; MI; [ChemIDplus] 2-Methyl-2,3-dihydroisothiazol-3-one; [ACGIH Guide to Occupational Exposure Values, 2002] MIT; Neolone 950; [Merck Index] 2-Methylisothiazol-3(2H)-one; [ToxPlanet: EC: SCCS - Opinion] UN3261
Category
Biocides/Disinfectants
Description
Colorless solid; [Merck Index] Dark yellow powder with lumps; [Sigma-Aldrich MSDS]
Sources/Uses
Used as a biocide and preservative in cosmetics, paints, and glues; it is present in Kathon KG, MCI/MI, and Euxyl K100; [Kanerva, p. 1815] Used as an antimicrobial in cosmetics, hygiene products, paints, emulsions, cutting oils, paper coatings, and water storage and cooling units; [Merck Index] Used as a biocide in textile production; [ToxPlanet: Danish Ministry of the Environment] Used as a preservative in pesticide products; [ToxPlanet: EPA - Inert Reassessments] Used as a biocide in pulp/paper mills, industrial process and cooling water systems, oil field operations, and air cleaner systems, and as a preservative in adhesives, coatings, fuels, metalworking fluids, resin emulsions, paints, and wood products; [Reference #1]
Comments
Allergic contact dermatitis reported in workers using products containing this preservative; [Kanerva, p. 1815] Danger of skin sensitization; [MAK] Cosmetic preservative that is a recognized contact allergen in consumers; [ToxPlanet: EC: SCCS - Opinion] Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; May cause skin sensitization; Harmful by ingestion; Toxic by inhalation; [Sigma-Aldrich MSDS] See "ISOTHIAZOLINONES."
Reference Link
Exposure Assessment
MAK
0.2 mg/m3, inhalable fraction
Explanatory Notes
The Guide in the Emergency Response Guidebook is for "Corrosive solid, acidic, organic, n.o.s." MAK value is for 3:1 mixture of 26172-55-4 and 2682-20-4;
Adverse Effects
Skin Sensitizer
Yes
Toxic Pneumonitis
Yes
Dermatotoxin
Skin Burns
Links to Other NLM Databases
Toxicity Information
Chemical Information
Biomedical References
Related Information in HazMap
Processes
Industrial Processes with risk of exposure: