Agent Name | Methylisothiazolinone |
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CAS Number | 2682-20-4 |
Formula | C4-H5-N-O-S |
Major Category | Other Uses |
Synonyms | 2-Methyl-3(2H)-isothiazolone; 2-Methyl-4-isothiazolin-3-one; 2-Methyl-2H-isothiazol-3-one; 2-Methyl-4-isothiazolin-3-one calcium chloride; 3(2H)-Isothiazolone, 2-methyl-; MI; [ChemIDplus] 2-Methyl-2,3-dihydroisothiazol-3-one; [ACGIH Guide to Occupational Exposure Values, 2002] MIT; Neolone 950; [Merck Index] 2-Methylisothiazol-3(2H)-one; [ToxPlanet: EC: SCCS - Opinion] UN3261 |
Category | Biocides/Disinfectants |
Description | Colorless solid; [Merck Index] Dark yellow powder with lumps; [Sigma-Aldrich MSDS] |
Sources/Uses | Used as a biocide and preservative in cosmetics, paints, and glues; it is present in Kathon KG, MCI/MI, and Euxyl K100; [Kanerva, p. 1815] Used as an antimicrobial in cosmetics, hygiene products, paints, emulsions, cutting oils, paper coatings, and water storage and cooling units; [Merck Index] Used as a biocide in textile production; [ToxPlanet: Danish Ministry of the Environment] Used as a preservative in pesticide products; [ToxPlanet: EPA - Inert Reassessments] Used as a biocide in pulp/paper mills, industrial process and cooling water systems, oil field operations, and air cleaner systems, and as a preservative in adhesives, coatings, fuels, metalworking fluids, resin emulsions, paints, and wood products; [Reference #1] |
Comments | Allergic contact dermatitis reported in workers using products containing this preservative; [Kanerva, p. 1815] Danger of skin sensitization; [MAK] Cosmetic preservative that is a recognized contact allergen in consumers; [ToxPlanet: EC: SCCS - Opinion] Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; May cause skin sensitization; Harmful by ingestion; Toxic by inhalation; [Sigma-Aldrich MSDS] See "ISOTHIAZOLINONES." |
Reference Link | |
Exposure Assessment | |
MAK | 0.2 mg/m3, inhalable fraction |
Explanatory Notes | The Guide in the Emergency Response Guidebook is for "Corrosive solid, acidic, organic, n.o.s." MAK value is for 3:1 mixture of 26172-55-4 and 2682-20-4; |
Adverse Effects | |
Skin Sensitizer | Yes |
Toxic Pneumonitis | Yes |
Dermatotoxin | Skin Burns |
Links to Other NLM Databases | |
Toxicity Information | |
Chemical Information | |
Biomedical References | |
Related Information in HazMap | |
Diseases | Occupational diseases associated with exposure to this agent: |
Processes | Industrial Processes with risk of exposure: |