Agent Name

Phenmedipham

CAS Number

13684-63-4

Formula

C16-H16-N2-O4

Major Category

Pesticides

Synonyms

3-((Methoxycarbonyl)amino)phenyl (3-methylphenyl)carbamate; 3-(Carbomethoxyamino)phenyl 3-methylcarbanilate; 3-(Methylphenyl)carbamic acid 3-((methoxycarbonyl)amino)phenyl ester; 3-Methoxycarbonyl-N-(3'-methylphenyl)-carbamat [German]; 3-Methoxycarbonylaminophenyl 3'-methylcarbanilate; 3-Methoxycarbonylaminophenyl N-3'-methylphenylcarbamate; Betanal; Carbanilic acid, m-hydroxy, methyl ester, m-methylcarbanilate (ester); EP-452; Fenmedifam; Kemifam; Methyl 3-(3-methylcarbaniloyloxy)carbanilate; Methyl 3-(m-tolylcarbamoyloxy)phenylcarbamate; Methyl N-(3-(N-(3-methylphenyl)carbamoyloxy)phenyl)carbamate; Methyl m-hydroxycarbanilate m-methylcarbanilate (ester) (8CI); Methyl m-hydroxycarbanilate, m-methylcarbanilate; Methyl-3-hydroxycarbanilate-3-methylcarbanilate; Methyl-3-m-tolycarbamoloxyphenyl carbamate; Morton EP 452; Phenmediphame [ISO-French]; S 4075; SN 4075; SN-38584; Schering 4072; Schering-38584; Spin-aid; Synbetan P; m-Hydroxycarbanilic acid methyl ester m-methylcarbanilate; Carbamic acid, (3-methylphenyl)-, 3-((methoxycarbonyl)amino)phenyl ester; [ChemIDplus]

Category

Herbicides, Other

Description

Colorless solid; [Merck Index] Colorless odorless solid; Formulated as technical solid and emulsifiable concentrate; [EPA REDs]

Sources/Uses

Used as a post-emergent herbicide; [Kanerva, p. 783] Used as a broadleaf herbicide for sugar and table beets, spinach, and Swiss chard grown for seed (over 98% used on sugar beets); [EPA REDs]

Comments

Allergic and photoallergic contact dermatitis reported in farmers; [Kanerva, p. 783] Emergency treatment: "Carbamate herbicides and fungicides"; [HSDB] The erythrocyte is the primary target of toxicity with hemolytic anemia observed in sub-chronic (rat, mouse, and dog) and chronic (rat) feeding studies; Methemoglobinemia and other hematological changes also seen in some studies; The severity of hematological effects noted in sub-chronic studies did not progress with time as evidenced in chronic studies; No developmental toxicity observed at the highest tested dose in rats (1,350 mg/kg/day) or rabbits (1,000 mg/kg/day) by gavage during gestation; [EPA REDs] May cause irritation; Toxic by skin absorption; [Aldrich MSDS]

Reference Link

Allergic contact dermatitis from Betanal (phenmedipham)

Exposure Assessment
Vapor Pressure

1.0E-11 mm Hg

Reference Link

Photoallergic dermatitis caused by the herbicide phenmedipham

Adverse Effects
Skin Sensitizer

Yes

Methemoglobinemia

Methemoglobinemia, Secondary

Dermatotoxin

Contact Dermatitis, Photoallergic

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: