Agent Name

Furazolidone

CAS Number

67-45-8

Formula

C8-H7-N3-O5

Major Category

Other Uses

Synonyms

2-Furanmethanimine, 5-nitro-N-(2-oxo-3-oxazolidinyl)-; 2-Oxazolidinone, 3-(((5-nitro-2-furanyl)methylene)amino)-; 2-Oxazolidinone, 3-((5-nitrofurfurylidine)amino)-; 3-(((5-Nitro-2-furanyl)methylene)amino)-2-oxazolidinone; 3-((5-Nitrofurfurylidene)amino)-2-oxazolidinone; 3-((5-Nitrofurfurylidene)amino)-2-oxazolidone; 3-((5-Nitrofurylidene)amino)-2-oxazolidone; 3-(5'-Nitrofurfuralamino)-2-oxazolidone; 5-Nitro-N-(2-oxo-3-oxazolidinyl)-2-furanmethanimine; Bifuron; Corizium; Coryzium; Diafuron; Enterotoxon; Furall; Furaxon; Furaxone; Furazol; Furazolidine; Furazolidon; Furazolidona [INN-Spanish]; Furazolidonum [INN-Latin]; Furazolum; Furazon; Furidon; Furovag; Furox; Furox Aerosol Powder (Veterinary); Furoxal; Furoxane; Furoxon; Furoxone; Furoxone swine mix; Furozolidine; Giardil; Giarlam; Medaron; N-(5-Nitro-2-furfurylidene)-3-amino-2-oxazolidone; N-(5-Nitro-2-furfurylidene)-3-aminooxazolidine-2-one; NF 180 custom mix ten; NF-180; Neftin; Nicolen; Nifulidone; Nifuran; Nifurazolidonum; Nitrofurazolidone; Nitrofurazolidonum; Nitrofuroxon; Optazol; Ortazol; Puradin; Roptazol; Sclaventerol; Tikofuran; Topazone; Trichofuron; Tricofuron; Tricoron; Trifurox; Viofuragyn; [ChemIDplus]

Category

Animal Feed Additives

Description

Yellow odorless solid; [Merck Index]

Sources/Uses

A Nitrofuran derivative with antiprotozoal and antibacterial activity. It has been used in giardiasis and in bacterial intestinal infections. Furazolidone acts by gradual inhibition of monoamine oxidase; [ChemIDplus] Used as a human topical anti-infective and antiprotozoal and veterinary antimicrobial; [Merck Index]

Comments

Allergic contact dermatitis (ACD) reported in feed mill workers; [Kanerva, p. 1798] Reports of ACD in livestock employees (animal feed/medication); Causes cytotoxic effects on the testes and atrophy and degeneration of the seminiferous tubules within one week of oral administration in rats; Chronic toxicity in rats and dogs manifests as CNS symptoms and effects on spermatogenesis; [HSDB]

Reference Link

Contact allergy to furazolidone

Exposure Assessment
Vapor Pressure

2.6E-6 mm Hg

Reference Link

Allergic contact dermatitis due to furazolidone in a piglet medication

Adverse Effects
Skin Sensitizer

Yes

IARC Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: