Agent Name

Thiabendazole

CAS Number

148-79-8

Formula

C10-H7-N3-S

Major Category

Other Uses

Synonyms

1H-Benzimidazole, 2-(4-thiazolyl)-; 2-(1,3-Thiazol-4-yl)benzimidazole; 2-(4-Thiazolyl)-1H-benzimidazole; 2-(4-Thiazolyl)benzimidazole; 2-Thiazole-4-ylbenzimidazole; 4-(2-Benzimidazolyl)thiazole; APL-luster; Benzimidazole, 2-(4-thiazolyl)-; Biogard; Bioguard; Bovizole; Captan T; Chemviron TK 100; Cropasal; E-Z-Ex; Eprofil; Equizole; Equizole A; G 491; Helmindrax octelmin; Hokustar HP; Lombristop; MK 360; MK-360; Mertec; Mertect; Mertect 160; Metasol TK-100; Mintesol; Mintezol; Mintezole; Minzolum; Mycozol; Nemapan; Omnizole; Ormogal; Pitrizet; Polival; RPH; RTU Flowable Fungicide; Rival; Sanaizol 100; Sistesan; Storite; Syntol M100; TBZ; TBZ 60W; TBZ-6; Tbdz; Tebuzate; Tecto 10P; Tecto 40F; Tecto 60; Tecto RPH; Testo; Thiaben; Thiabendazol; Thiabendazole [BSI:ISO]; Thiabendazolum; Thiabenzole; Thibenzol; Thibenzole; Thibenzole 200; Thibenzole ATT; Tiabenda; Tiabendazol [INN-Spanish, French]; Tiabendazole; Tiabendazolum [INN-Latin]; Tobaz; Top form wormer; Triasox; [ChemIDplus]

Category

Animal Feed Additives

Description

Colorless, white, or tan odorless solid; [HSDB] Colorless solid; [EPA REDs] Off-white to yellow-tan solid; [ToxPlanet: CPSQ]

Sources/Uses

Used to treat roundworm infections in animals and humans; also added to animal feed; [Kanerva, p. 1839] Used as a paint biocide; [Adams, p. 475] Used as a fungicide for potatoes and citrus fruit, for treatment and prevention of Dutch elm disease in trees, and as a human anthelmintic and veterinary anthelmintic and fungicide; [Merck Index] Used as a fungicide for various fruits and vegetables, soybeans, and wheat (seed treatment and post-harvest dip or spray); Also used to preserve paints, carpet, adhesives, paper products, and textiles; [EPA REDs] Used as a wood preservative; [ExPub: CPSQ]

Comments

Allergic contact dermatitis (ACD) reported in feed mill workers; [Kanerva, p. 1839] Ingestion of high doses can cause hepatic injury. [Zimmerman, p. 412] Reports of liver injury, CNS effects, and hypersensitivity reactions (rashes, conjunctivitis, erythema multifomre, Stevens-Johnson syndrome, and angioedema) in patients; Report of ACD in banana plantation employees; [HSDB] The hypophosphite salt (CAS# 28558-32-9) is used in the non-food applications; Not irritating to skin or eyes and not a skin sensitizer; May interfere with thyroid-pituitary homeostasis; "Likely to be carcinogenic at doses high enough to cause disturbance of the thyroid hormone balance. It is not likely to be carcinogenic at doses lower than those which could cause a disturbance of this hormonal balance. [EPA REDs]

Reference Link

Occupational dermatitis in animal feed mill workers

Exposure Assessment
MAK

20 mg/m3, inhalable fraction

Vapor Pressure

4.0E-9 mm Hg

Reference Link

EXTOXNET PIP - THIABENDAZOLE

Adverse Effects
Skin Sensitizer

Yes

Hepatotoxin

Hepatotoxin, Secondary

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: