Agent Name

Buthionine sulfoximine

CAS Number

5072-26-4

Formula

C8-H18-N2-O3-S

Major Category

Other Uses

Synonyms

2-Amino-4-(S-butylsulfonimidoyl)butanoic acid; Buthione sulfoximine; Buthionine sulfoxamine; Buthionine sulphoximine; Butionine sulfoximine; Sulfoximine, S-(3-amino-3-carboxypropyl)-S-butyl-; Butanoic acid, 2-amino-4-(S-butylsulfonimidoyl)-; [ChemIDplus] S-(3-Amino-3-carboxypropyl)-S-butylsulfoximine; S-(-n-Butyl)homocysteine sulfoximine; BSO; [Merck Index]

Category

Biochemical Research

Description

Solid; [Merck Index]

Sources/Uses

Used as a "biological tool for depletion of glutathione"; [Merck Index]

Comments

Causes lung changes, effects on lipids and proteins, liver changes, and maternal reproductive effects in acute intraperitoneal studies of rats; Causes diffuse hepatitis in 2-week intermittent subcutaneous studies of guinea pigs; [RTECS] A skin and strong eye irritant; [Sigma-Aldrich MSDS]

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

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