Agent Name

Diglycidyl ether

Alternative Name

DGE

CAS Number

2238-07-5

Formula

C6-H10-O3

Major Category

Plastics & Rubber

Synonyms

DGE; 1,2,6,7-Diepoxy-4-oxaheptane; Bis(2,3-epoxy-1 propyl) ether; Bis(2,3-epoxypropyl) ether; DGE; Di(2,3-epoxy)propyl ether; Diallyl Ether Dioxide; Diepoxy propyl ether; Diglycidyl ether; Ether, bis(2,3-epoxypropyl); Ether, diglycidyl; Glycidyl ether; [ChemIDplus]

Category

Glycidyl Ethers

Description

Colorless liquid with a strong, irritating odor; [NIOSH]

Sources/Uses

DGE is used in epoxy resins; it is also used to treat textiles and to stabilize chlorinated organic compounds. [ACGIH]

Comments

The TLV is based on male reproductive effects and irritation to the skin and eyes. Male rats develop reproductive toxicity after 60 4-hour exposures to 0.3 ppm. High concentrations induce CNS depression in experimental animals. In the past, some workers developed slow healing burns. [ACGIH] Severely irritating to the respiratory tract and may cause pulmonary edema; May cause skin sensitization; [ICSC]

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

0.01 ppm

PEL (OSHA)

Ceiling(OSHA) = 0.5 ppm

IDLH (NIOSH)

10 ppm

Excerpts from Documentation for IDLHs

Basis for original (SCP) IDLH: The chosen IDLH is based on the male mouse 4hour LC50 of 30 ppm [Hine et al. 1956]. . . . Human data: None relevant for use in determining the revised IDLH.

Vapor Pressure

0.09 mm Hg

Odor Threshold Low

5 ppm

Lethal Concentration

LC50 (rat) = 200 ppm/4H

Explanatory Notes

An odor threshold has not been established, but DGE is recognizable by odor above 5 ppm; [ACGIH] Flash point = 64 deg C;

Adverse Effects
Skin Sensitizer

Yes

Toxic Pneumonitis

Yes

Reproductive Toxin

Yes

Dermatotoxin

Skin Burns

ACGIH Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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