Agent Name

Tumor Necrosis Factor-alpha

CAS Number

308079-78-9

Major Category

Biological Agents

Synonyms

Cachectin; Cachectin proteins; Cachectins; Lymphokines and Cytokines, tumor necrosis factor; TNF; TNF Receptor Ligands; TNF alpha; TNF-alpha; TNFalpha; Tumor Necrosis Factors; Tumor necrosis factor; Tumor necrosis factor alpha; [ChemIDplus] Mouse Tumor Necrosis Factor alpha; mTNF alpha; [Cell Signaling MSDS]

Category

Proteins

Description

Powder; [Cell Signaling MSDS]

Sources/Uses

"Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta ( LYMPHOTOXIN), but they share TNF RECEPTORS." [ChemIDplus] "Tumor necrosis factor (TNF, cachexin, or cachectin, and formerly known as tumor necrosis factor-alpha or TNF-a) is a cytokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase reaction. It is produced chiefly by activated macrophages (M1), although it can be produced by many other cell types as CD4+ lymphocytes, NK cells and neurons. The primary role of TNF is in the regulation of immune cells." [Wikipedia]

Comments

An irritant; [Cell Signaling MSDS]

Links to Other NLM Databases
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