Agent Name

Campesterol

CAS Number

474-62-4

Formula

C28-H48-O

Major Category

Biological Agents

Synonyms

(24R)-5-Ergosten-3beta-ol; 24-Methylcholesterol; 24alpha-Methylcholesterol; Campesterin; delta5-24-Isoergosten-3beta-ol; (24R)-Ergost-5-en-3beta-ol; Ergost-5-en-3-ol, (3beta,24R)-; Ergost-5-en-3beta-ol, (24R)- (8CI); [ChemIDplus] (3beta,24R)-Ergost-5-en-3-ol; [Merck Index] 24alpha-Methyl-5-cholesten 3beta-ol; 24(R)-Ergost-5-en-3beta-ol; [Sigma-Aldrich MSDS]

Category

Plant Oils and Extracts

Description

Solid; [Merck Index] White crystalline solid; [Sigma-Aldrich MSDS]

Sources/Uses

Present in rape-seed oil, soybean oil, and wheat germ oil; [Merck Index] Added to food as a source of phytosterols (for blood cholesterol lowering properties); [JECFA]

Comments

Phytosterol esters containing 26-29% campesterol demonstrate no significant adverse effects in a 90-day oral study of rats; Phytosterol esters containing 27.9% campesterol produced decreased body weights, increased frequency of cardiomyopathy (males), and changes in hematology parameters in a 13-week oral study of rats at the highest tested dose (9,000 mg/kg/day); Phytosterol esters show no evidence of reproductive or developmental toxicity in rats; [JECFA] A moderate irritant; Harmful by ingestion, inhalation, and skin absorption; Targets the eyes, kidney, liver, and heart; [Sigma-Aldrich MSDS]

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