Agent Name

Caryophyllene

CAS Number

87-44-5

Formula

C15-H24

Major Category

Biological Agents

Synonyms

2-Methylene-6,10,10-trimethylbicyclo(7.2.0)undec-5-ene; 4,11,11-Trimethyl-8-methylenebicyclo(7.2.0)undec-4-ene, (1R-(1R*,4E,9S*))-; 8-Methylene-4,11,11-(trimethyl)bicyclo(7.2.0)undec-4-ene; Bicyclo(7.2.0)undec-4-ene, 4,11,11-trimethyl-8-methylene-, (1R-(1R*,4E,9S*))-; L-Caryophyllene; beta-Caryophyllen; beta-Caryophyllene (natural); l-Caryophyllene; Bicyclo(7.2.0)undec-4-ene, 4,11,11-trimethyl-8-methylene-, (1R,4E,9S)-; Bicyclo(7.2.0)undec-4-ene, 8-methylene-4,11,11-trimethyl-, (E)-(1R,9S)-(-)-; beta-Caryophyllene; [ChemIDplus] trans-Caryophyllene; (1R,4E,9S)-4,11,11-Trimethyl-8-methylenebicyclo[7.2.0]undec-4-ene; [Merck Index] 1-Caryophyllene; (-)-beta-Caryophyllene; beta-Caryophyllene, (-); Bicyclo[7.2.0]undec-4-ene, 4,11,11-trimethyl-8-methylene-, (E)-(1R,9S)-(-)-; (-)-Caryophyllene; (-)-E-Caryophyllene; (-)-trans-Caryophyllene; [CAMEO]

Category

Plant Oils and Extracts

Description

Liquid with a terpene odor between cloves and turpentine; [Merck Index] Pale yellow oily liquid; [CAMEO] Clear colorless liquid with a sweet woody odor;

Sources/Uses

Found in many essential oils, especially clove oil; Used in perfumes; [Merck Index] Used as flavoring agent or adjuvant and coloring agent for foods; [FDA] Also used to suppress intestinal bacteria; [NTP]

Comments

A skin irritant; [NTP] Safe when used as a flavoring agent in food; [JECFA] Causes local anesthesia in acute ocular studies of rabbits; Causes inflammation in acute oral studies of mice; [RTECS] beta-Caryophyllene (oxidized) included in list of "established contact allergens in humans"; [ToxPlanet: EC: Scientific Committee on Consumer Safety: Fragrance allergens in cosmetic products (2011)] A skin irritant; Harmful by ingestion (may cause lung damage by aspiration); [Good Scents MSDS]

Reference Link

The fragrance chemical beta-caryophyllene-air oxidation and skin sensitization.

Adverse Effects
Skin Sensitizer

Yes

Links to Other NLM Databases
Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: