Agent Name

Phenyl glycidyl ether

Alternative Name

PGE

CAS Number

122-60-1

Formula

C9-H10-O2

Major Category

Plastics & Rubber

Synonyms

PGE; (+/-)-(2,3-Epoxypropyl)phenylether; (Phenoxymethyl)oxirane; 1,2-Epoxy-3-phenoxypropane; 1-Phenoxy-2,3-epoxypropane; 2,3-Epoxy-1-phenoxypropane; 2,3-Epoxypropyl phenyl ether; 2,3-Epoxypropylphenyl ether; 3-Phenoxy-1,2-epoxypropane; 3-Phenoxy-1,2-propylene oxide; 3-Phenyloxy-1,2-epoxypropane; Ageflex PGE; Benzene, (2,3-epoxypropoxy)-; Ether, 2,3-epoxypropyl phenyl; Ether, phenylglycidyl; Fenyl-glycidylether [Czech]; Glycidol phenyl ether; Glycidyl phenyl ether; Heloxy WC-63; Oxirane, (phenoxymethyl)-; PGE; Phenol glycidyl ether; Phenol-glycidaether [German]; Phenoxypropene oxide; Phenoxypropylene oxide; Phenyl 2,3-epoxypropyl ether; Phenylglycidyl ether; Phenylglycydyl ether; Propane, 1,2-epoxy-3-phenoxy-; [ChemIDplus] UN8027

Category

Glycidyl Ethers

Description

Colorless liquid. [Note: A solid below 38 degrees F.] [NIOSH]

Sources/Uses

Glycidyl ethers are used as reactive diluents in epoxy resins. [LaDou, p. 550] Allergic contact dermatitis in shoemakers; [Marks] As a reactive diluent in uncured epoxy resins, it reduces viscosity in casting , adhesive and laminating applications; [ACGIH]

Comments

PGE is a testicular toxin in male rats exposed by inhalation at 12 ppm for 19 days. [ACGIH] A skin irritant and sensitizer; [ICSC] Can cause narcosis, reproductive effects, and possible hematopoietic effects; [CAMEO] Animals have CNS depression and evidence of liver injury in high-dose studies. [HSDB]

Exposure Assessment
Skin Designation (ACGIH)

Yes

TLV (ACGIH)

0.1 ppm

PEL (OSHA)

10 ppm

IDLH (NIOSH)

100 ppm

Excerpts from Documentation for IDLHs

ACGIH [1971] reported that 10 rats exposed to 100 ppm phenyl glycidyl ether 7 hours/day for 50 days exhibited no immediately obvious signs of toxicity, and no deaths occurred [Hine et al. 1956].

Vapor Pressure

0.01 mm Hg

Lethal Concentration

LC50 (rat) >100 ppm/8h

Explanatory Notes

Flash point = 248 deg F;

Reference Link

ICSC: Phenyl glycidyl ether

Adverse Effects
Skin Sensitizer

Yes

Hepatotoxin

Hepatotoxin, Secondary

Reproductive Toxin

Yes

IARC Carcinogen

Possible Carcinogen

ACGIH Carcinogen

Confirmed Animal

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

Search ChemIDplus

Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: