Agent Name

Demecolcine

Alternative Name

Colcemid

CAS Number

477-30-5

Formula

C21-H25-N-O5

Major Category

Other Uses

Synonyms

(-)-Colchamine; (-)-Demecolcine; 6,7-Dihydro-1,2,3,10-tetramethoxy-7-(methylamino)-benzo(alpha)heptalen-9(5H)-one; Alkaloid H 3, from colchicum antumnale; C-12669; Ciba 12669A; Colcemid; Colchamine; Colchicine, 7-deacetamido-7-(methylamino)-; Colchicine, N-deacetyl-N-methyl-; Deacetyl-N-methylcolchicine; Deacetylmethylcolchicine; Demecolcin; Demecolcina [INN-Spanish]; Demecolcinum [INN-Latin]; Desacetylmethylcolchicine; Desmecolcine; Kolchamin; Kolchicin [Czech]; Kolkamin; N-Deacetyl-N-methylcolchicine; N-Desacetyl-N-methylcolchicine; N-Desacetylmethylcolchicine; N-Methyl-N-deacetylcolchicine; N-Methyl-N-desacetylcolchicine; Omain; Omaine; Reichstein's F; Santavy's substance F; Substance F; X 153; Benzo(a)heptalen-9(5H)-one, 6,7-dihydro-1,2,3,10-tetramethoxy-7-(methylamino)-, (S)-; [ChemIDplus]

Category

Biochemical Research

Description

Pale yellow solid; [Merck Index] Light yellow crystalline solid; [Sigma-Aldrich MSDS]

Sources/Uses

An anti-tumor alkaloid; Used as a "cell synchronization agent, for chromosome visualization, to induce oocyte enucleation for somatic cell cloning." [Merck Index]

Comments

Causes somnolence and diarrhea in intravenous lethal-dose studies of mice; [RTECS] May cause irritation; Highly toxic by ingestion; Targets bone marrow; Teratogenic and mutagenic effects observed in laboratory studies; [Sigma-Aldrich MSDS]

Exposure Assessment
Vapor Pressure

1.48E-9 mm Hg

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