Agent Name

2-Ethoxyethanol

Alternative Name

EGEE

CAS Number

110-80-5

Formula

C4-H10-O2

Major Category

Solvents

Synonyms

2-Ethoxyethanol; 2-Ethoxyethyl alcohol; Bikanol E 1; Cellosolve; Cellosolve solvent; Dowanol 8; Dowanol EE; EGEE; Ektasolve EE; Emkanol; Ethanol, 2-ethoxy-; Ethyl cellosolve; Ethyl ethylene glycol; Ethylene glycol ethyl ether; Ethylene glycol monoethyl ether; Ethylethylene glycol; Glycol monoethyl ether; Hydroxy ether; Jeffersol EE; Oxitol; Plastiazan 60; Poly-Solv EE; RCRA waste number U359; Solvid; Solvulose; beta-Ethoxyethanol; [ChemIDplus] UN1171

Category

Glycol Ethers (E Series)

Description

Colorless liquid with a sweet, pleasant, ether-like odor; [NIOSH]

Sources/Uses

Used as an industrial solvent and anti-icing additive to aviation fuels; [ACGIH] Used as a solvent for coatings, inks, adhesives, textile dyes, lacquers, and epoxy resins; [HSDB] Not produced commercially in the EU; [Glycol Ethers Online]

Comments

Changes in the lungs, kidneys, liver, and spleen are seen in mice after 7-hour lethal concentration studies. For ethylene glycol ethers, there is limited positive evidence of spontaneous abortions and decreased sperm counts in humans and strong positive evidence of birth defects and testicular damage in animals. [ATSDR Case Studies # 29] Labeled as "May impair fertility" and "May cause harm to the unborn child" by EU regulations; [Glycol Ethers Online] See "Glycol ethers."

Exposure Assessment
BEI

2-Ethoxyacetic acid in urine = 100 mg/g creatinine; end of shift at end of workweek;

Skin Designation (ACGIH)

Yes

TLV (ACGIH)

5 ppm

PEL (OSHA)

200 ppm

MAK

2 ppm, sum of the concentrations of CAS 110-80-5 and its acetate in air

IDLH (NIOSH)

500 ppm

Excerpts from Documentation for IDLHs

Other animal data: Some investigators have stated that at ordinary room temperatures substantially saturated atmospheres (i.e., about 6,000 ppm) will not produce serious injury in 1 hour [Waite et al. 1930]. Human data: Volunteers with some work experience reported that odor levels of 125 ppm were noticeable and that the odor level that would be intolerable was greater than 255 ppm [Clayton and Clayton 1982].

Vapor Pressure

5.31 mm Hg

Odor Threshold Low

0.3 ppm

Odor Threshold High

24 ppm

Lethal Concentration

LC50 (rat) = 2,000 ppm/7 hr

Explanatory Notes

Detection odor threshold from AIHA (mean = 2.7 ppm); Flash point = 43 deg C;

Reference Link

ICSC: Ethylene glycol monoethyl ether

Flammability (NFPA)

2: High ambient temperature required

Adverse Effects
Anemia

Anemia, Aplastic

Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Secondary

Reproductive Toxin

Yes

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Biomedical References

Search PubMed

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: