Agent Name

2-Ethoxyethyl acetate

Alternative Name

EGEEA

CAS Number

111-15-9

Formula

C6-H12-O3

Major Category

Solvents

Synonyms

Ethylene glycol monoethyl ether acetate; 1-Acetoxy-2-ethoxyethane; 2-Aethoxy-aethylacetat [German]; 2-Ethoxy-ethylacetaat [Dutch]; 2-Ethoxyethanol acetate; 2-Ethoxyethanol, ester with acetic acid; 2-Ethoxyethyl acetate; 2-Ethoxyethylacetate; 2-Ethoxyethyle, acetate de [French]; 2-Ethoxyethylester kyseliny octove [Czech]; 2-Etossietil-acetato [Italian]; Acetate d'ethylglycol [French]; Acetate de cellosolve [French]; Acetate de l'ether monoethylique de l'ethylene-glycol; [French]; Acetato di cellosolve [Italian]; Acetic acid, 2-ethoxyethyl ester; Aethylenglykolaetheracetat [German]; Cellosolve acetate; Celosolvacetat [Czech]; EGEEA; Ektasolve EE acetate solvent; Ethanol, 2-ethoxy-, acetate; Ethoxyethyl acetate; Ethyl cellosolve acetaat [Dutch]; Ethyl cellosolve acetate; Ethylene glycol ethyl ether acetate; Ethylene glycol monoethyl ether acetylated; Ethylene glycol monoethyl ether monoacetate; Ethyleneglycol monoethyl ether acetate; Ethylglycol acetate; Ethylglykolacetat [German]; Glycol ether EE acetate; Glycol monoethyl ether acetate; Octan etoksyetylu [Polish]; Oxitol acetate; Oxytol acetate; Poly-Solv EE acetate; [ChemIDplus] UN1172

Category

Glycol Ethers (E Series)

Description

Colorless liquid with a mild odor; [NIOSH]

Sources/Uses

Used as an industrial solvent; [ACGIH]

Comments

Laboratory animals die after twelve 8-hour exposures of 450 ppm; pathological examination shows kidney damage; [ACGIH] For ethylene glycol ethers, there is limited positive evidence of spontaneous abortions and decreased sperm counts in humans and strong positive evidence of birth defects and testicular damage in animals. [ATSDR Case Studies # 29] See "Glycol ethers."

Restricted

The Semiconductor Industry Association recommends elimination of this solvent because of potential reproductive effects. [CHS, p. 43]

Exposure Assessment
BEI

2-Ethoxyacetic acid in urine = 100 mg/g creatinine; end of shift at end of workweek;

Skin Designation (ACGIH)

Yes

TLV (ACGIH)

5 ppm

PEL (OSHA)

100 ppm

MAK

2 ppm, sum of the concentrations of CAS 110-80-5 and its acetate in air

IDLH (NIOSH)

500 ppm

Excerpts from Documentation for IDLHs

Basis for original (SCP) IDLH: Patty [1963] reported that guinea pigs survived a 1hour exposure to an atmosphere essentially saturated with vapor (estimated to be less than 4,000 ppm) [Lehmann and Flury 1943]. Because the data concerning the concentration is not very specific, the IDLH is based on the concentration of 2ethoxyethylacetate in saturated air at 20 C (i.e., 2,600 ppm). . . . Human data: None relevant for use in determining the revised IDLH.

Vapor Pressure

2.34 mm Hg

Odor Threshold Low

0.06 ppm

Odor Threshold High

0.13 ppm

Lethal Concentration

LC50 (rat) = 12,100 mg/m3/8 hr

Explanatory Notes

Detection odor threshold from AIHA (mean = 0.06 ppm); Flash point = 47 degC;

Half Life

"The half life for elimination was 23.6 hours." [HSDB]

Reference Link

ICSC: 2-Ethoxyethyl acetate

Flammability (NFPA)

2: High ambient temperature required

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Secondary

Reproductive Toxin

Yes

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: