Agent Name

2-Ethoxyethyl acetate

Alternative Name

EGEEA

CAS Number

111-15-9

Formula

C6-H12-O3

Major Category

Solvents

Synonyms

Ethylene glycol monoethyl ether acetate; 1-Acetoxy-2-ethoxyethane; 2-Aethoxy-aethylacetat [German]; 2-Ethoxy-ethylacetaat [Dutch]; 2-Ethoxyethanol acetate; 2-Ethoxyethanol, ester with acetic acid; 2-Ethoxyethyl acetate; 2-Ethoxyethylacetate; 2-Ethoxyethyle, acetate de [French]; 2-Ethoxyethylester kyseliny octove [Czech]; 2-Etossietil-acetato [Italian]; Acetate d'ethylglycol [French]; Acetate de cellosolve [French]; Acetate de l'ether monoethylique de l'ethylene-glycol; [French]; Acetato di cellosolve [Italian]; Acetic acid, 2-ethoxyethyl ester; Aethylenglykolaetheracetat [German]; Cellosolve acetate; Celosolvacetat [Czech]; EGEEA; Ektasolve EE acetate solvent; Ethanol, 2-ethoxy-, acetate; Ethoxyethyl acetate; Ethyl cellosolve acetaat [Dutch]; Ethyl cellosolve acetate; Ethylene glycol ethyl ether acetate; Ethylene glycol monoethyl ether acetylated; Ethylene glycol monoethyl ether monoacetate; Ethyleneglycol monoethyl ether acetate; Ethylglycol acetate; Ethylglykolacetat [German]; Glycol ether EE acetate; Glycol monoethyl ether acetate; Octan etoksyetylu [Polish]; Oxitol acetate; Oxytol acetate; Poly-Solv EE acetate; [ChemIDplus] UN1172

Category

Glycol Ethers (E Series)

Description

Colorless liquid with a mild odor; [NIOSH]

Sources/Uses

Used as an industrial solvent; [ACGIH]

Comments

Laboratory animals die after twelve 8-hour exposures of 450 ppm; pathological examination shows kidney damage; [ACGIH] For ethylene glycol ethers, there is limited positive evidence of spontaneous abortions and decreased sperm counts in humans and strong positive evidence of birth defects and testicular damage in animals. [ATSDR Case Studies # 29] See "Glycol ethers."

Restricted

The Semiconductor Industry Association recommends elimination of this solvent because of potential reproductive effects. [CHS, p. 43]

Exposure Assessment
BEI

2-Ethoxyacetic acid in urine = 100 mg/g creatinine; end of shift at end of workweek;

Skin Designation (ACGIH)

Yes

TLV (ACGIH)

5 ppm

PEL (OSHA)

100 ppm

MAK

2 ppm, sum of the concentrations of CAS 110-80-5 and its acetate in air

IDLH (NIOSH)

500 ppm

Excerpts from Documentation for IDLHs

Basis for original (SCP) IDLH: Patty [1963] reported that guinea pigs survived a 1hour exposure to an atmosphere essentially saturated with vapor (estimated to be less than 4,000 ppm) [Lehmann and Flury 1943]. Because the data concerning the concentration is not very specific, the IDLH is based on the concentration of 2ethoxyethylacetate in saturated air at 20 C (i.e., 2,600 ppm). . . . Human data: None relevant for use in determining the revised IDLH.

Vapor Pressure

2.34 mm Hg

Odor Threshold Low

0.06 ppm

Odor Threshold High

0.13 ppm

Lethal Concentration

LC50 (rat) = 12,100 mg/m3/8 hr

Explanatory Notes

Detection odor threshold from AIHA (mean = 0.06 ppm); Flash point = 47 degC;

Half Life

"The half life for elimination was 23.6 hours." [HSDB]

Reference Link

ICSC: 2-Ethoxyethyl acetate

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Secondary

Reproductive Toxin

Yes

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: